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Isogenous group

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Micrograph of hyaline cartilage containing isogenous groups.

An isogenous group (lat. "equal origin") is a cluster of up to eight chondrocytes found in hyaline and elastic cartilage.

Formation

Chondrocytes develop in the embryo from mesenchymal progenitor cells through a process known as chondrogenesis. A chondrocyte can then undergo mitosis to form an isogenous group within its lacuna.

Function

Isogenous groups differentiate into individual chondrocytes where they continue to produce and deposit extracellular matrix (ECM), lengthening the cartilage and increasing its diameter. This is termed interstitial growth and is one of only two ways cartilage can grow.

Cartoon representation of hyaline cartilage with isogenous groups.

See also

References

  1. Nahian, Ahmed; Sapra, Amit (2021), "Histology, Chondrocytes", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 32491508, retrieved 2021-11-28
  2. ^ Wheater's Functional Histology, 6th ed. Young, O'Dowd and Woodford.
  3. ^ Leboffe, Michael J. (2013). "Chapter 5: Cartilage and Bone". A Photographic Atlas of Histology Second Edition. Morton Publishing. pp. 51–55. ISBN 978-161731-068-3.
  4. ^ Hall, Brian K. (2005), "Chapter 3: Cartilage", Bones and Cartilage: Developmental and Evolutionary Skeletal Biology, Elsevier, p. 35, ISBN 9780080454153, retrieved 2021-11-28
  5. Asanbaeva, Anna; Masuda, Koichi; Thonar, Eugene J.-M. A.; Klisch, Stephen M.; Sah, Robert L. (2007). "Mechanisms of cartilage growth: Modulation of balance between proteoglycan and collagen in vitro using chondroitinase ABC". Arthritis & Rheumatism. 56 (1): 188–198. doi:10.1002/art.22298. ISSN 1529-0131. PMID 17195221.
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