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John Scott HaldaneFRS
Born	(1860-05-02)2 May 1860 Edinburgh, Scotland, United Kingdom of Great Britain and Ireland
Died	14 March 1936(1936-03-14) (aged 75) Oxford, England, United Kingdom
Nationality	Scottish
Education	Edinburgh Academy
Alma mater	University of Edinburgh Friedrich Schiller University of Jena
Known for	Black Veil Respirator Haldane effect Haldane's decompression model
Spouse	Louisa Kathleen Coutts Trotter
Children	J. B. S. Haldane Naomi Mitchison
Awards	Fellow of the Royal Society, member of the Royal College of Physicians and of the Royal Society of Medicine; many honorary degrees
Scientific career
Fields	Physiology, medicine
Institutions	University of Glasgow New College, Oxford University of Birmingham

John Scott Haldane CH FRS (/ˈhɔːldeɪn/; 2 May 1860 – 14/15 March 1936) was a Scottish physician physiologist and philosopher famous for intrepid self-experimentation which led to many important discoveries about the human body and the nature of gases. He also experimented on his son, the celebrated and polymathic biologist J. B. S. Haldane, even when he was quite young. Haldane locked himself in sealed chambers breathing potentially lethal cocktails of gases while recording their effect on his mind and body.

Haldane visited the scenes of many mining disasters and investigated their causes. When the Germans used poison gas in World War I, Haldane went to the front at the request of Lord Kitchener and attempted to identify the gases being used. One outcome of this was his invention of a respirator, known as the black veil.

Haldane's investigations into decompression sickness resulted in the concept of staged decompression, and the first reasonably reliable decompression tables, and his mathematical model is still used in highly modified forms for computing decompression schedules.

Background and family

Haldane was born in Edinburgh to Robert Haldane, whose father was Scottish evangelist James Alexander Haldane, and Mary Elizabeth Burdon-Sanderson, daughter of Richard Burdon-Sanderson and the granddaughter of Sir Thomas Burdon. His maternal uncle was the physiologist John Scott Burdon-Sanderson. He was the brother of Elizabeth Haldane, William Haldane and Richard Haldane, 1st Viscount Haldane.

On 12 December 1891 John Scott Haldane married Louisa Kathleen Coutts Trotter (1863–1961), daughter of Coutts Trotter FRGS and Harriet Augusta Keatinge. The couple had two children, the biologist J.B.S. 'Jack' Haldane (born in 1892) and the writer Naomi Mitchison (born in 1897). After the birth of Naomi, the family lived for a time in a house at 10 Randolph Crescent in Edinburgh's New Town before returning to Oxford. They spent summers at the Haldane family's country house at Cloan in Perthshire.

John Scott Haldane's nephew was the New Zealand doctor and public health administrator Robert Haldane Makgill.

Education

Haldane attended Edinburgh Academy, Edinburgh University and the Friedrich Schiller University of Jena. He graduated in medicine from Edinburgh University Medical School in 1884, after which he was a Demonstrator at University College, Dundee. From 1907 to 1913 he was a Reader in Physiology at Oxford University where his uncle, John Burdon-Sanderson, was Waynflete Professor of Physiology.

Haldane also published his philosophical ideas about the true significance of biology.

Career

Haldane was Gifford Lecturer in the University of Glasgow, Fellow of New College, Oxford, from October 1901, and Honorary Professor of the University of Birmingham. Haldane received numerous honorary degrees. He was also President of the English Institution of Mining Engineers, a Member of the Order of the Companions of Honour, a Fellow of the Royal Society, a member of the Royal College of Physicians and of the Royal Society of Medicine.

Haldane became a Fellow of the Royal Society in 1897, was a Royal Medallist of the Society in 1916, was appointed Member of the Order of the Companions of Honour in 1928 for work on industrial disease, and was a Copley Medallist in 1934.

Death

Haldane died in Oxford at midnight on the night of 14 March/15 March 1936 of pneumonia. He had just returned from a trip he had undertaken to investigate cases of heat stroke in the oil refineries in Persia.

Sir Henry Newbolt wrote a poem called "For J. S. Haldane", published in his anthology A Perpetual Memory and other Poems in 1939.

Accomplishments

Respiration and anaesthesia

Haldane was an international authority on ether and respiration and the inventor of the Black Veil Respirator, an early gas mask, during World War I.

He was also an authority on the effects of pulmonary diseases, such as silicosis caused by inhaling silica dust. After being forced out of combatting poison gases in World War I, through alleged German sympathies, he shifted into working with victims of gas warfare and developed oxygen treatment including the oxygen tent.

Haldane helped determine the regulation of breathing, and discovered the Haldane effect in haemoglobin: Deoxygenated haemoglobin has a greater affinity for carbon dioxide than oxygenated haemoglobin, so the release of oxygen from the capillaries to the tissues facilitates the removal of carbon dioxide in those capillaries, and in the lung capillaries the high oxygenation of the blood promotes the release of carbon dioxide to the plasma, which allows it to diffuse into the alveolar gas.

Haldane was the founder of The Journal of Hygiene.

Diving physiology

In 1907 Haldane had a decompression chamber made at the Lister Institute for his experimental work which was to help make underwater diving safer and produced the first decompression tables using his concept of stage decompression after extensive experiments with animals, and with divers in Scottish deep-water lochs. The decompression experiments examined the depth and pressure exposure, duration, and the pattern of decompression. Initial experiments used rabbits, guinea pigs, rats and mice, but the difficulty of detecting symptoms in the smaller animals led to the choice of goats, which were the largest animals easily available that were conveniently manageable in the available facilities.

The mathematical model on which these tables were based, though considerably revised and modified, remains a widely accepted method of decompressing divers from non-saturation exposures. In 1908, Haldane published the findings with A. E. Boycott and G. C. C. Damant in the paper "Prevention of Compressed-Air Illness" in the Journal of Hygiene. He also found by experiment that part of the cause for divers losing consciousness while working at around 120 feet in standard helmets was a buildup of carbon dioxide in the helmet caused by insufficient ventilation, and established a minimum flow rate of 1.5 cubic feet (42 L) per minute at ambient pressure.

Coal and other mining incidents

He investigated the principle of action of many different gases. He investigated numerous mine disasters, especially the toxic gases which killed most miners after firedamp and coal dust explosions. The toxic mixtures of gases found in mines included afterdamp, blackdamp and whitedamp. His description of the way a flame safety lamp can be used to detect firedamp by the increase in height of the flame, and chokedamp by the dying of the flame, is a classic exposition in his textbook, Respiration. Although electronic gas detectors are now used widely in all coal mines, flame lamps are still used extensively for their ease and simplicity of operation. He identified carbon monoxide as the lethal constituent of afterdamp, the gas created by combustion, after examining many bodies of miners killed in pit explosions. Their skin was coloured cherry-pink from carboxyhaemoglobin, the stable compound formed in the blood by reaction with the gas. It effectively displaces oxygen, and so the victim dies of asphyxia. As a result of his research, he was able to design respirators for rescue workers. He tested the effect of carbon monoxide on his own body in a closed chamber, describing the results of his slow poisoning.

In the late 1890s, Haldane introduced the use of small animals for miners to detect dangerous levels of carbon monoxide underground, either white mice or canaries. With a faster metabolism, they showed the effects of poisoning before gas levels became critical for the workers, and so gave an early warning of the problem. The canary in British pits was replaced in 1986 by the electronic gas detector. Electronic gas detectors rely on a catalytic chip which can be poisoned by atmospheric impurities.

Pike's Peak expedition

Haldane pioneered the study of the reaction of the body to low air pressures, such as that experienced at high altitudes. He led an expedition to Pike's Peak in 1911, which examined the effect of low atmospheric pressure on respiration. Since then, Pike's Peak has continued to be a site of research into respiration.

Sewer gas

In addition to his work on mine atmospheres, he investigated the air in enclosed spaces such as wells and sewers. One surprising result of his analysis of the air in the sewers beneath the House of Commons was to show that the level of bacterial contamination was relatively low. During this research, he investigated fatalities of workmen in a sewer, and showed that hydrogen sulfide gas poisoning was the cause of death.

Bibliography

Writings

• J. S. Haldane, The Philosophical Basis of Biology: Donnellan Lectures, University of Dublin, 1930, Hodder and Stoughton Limited (1931).
• J. S. Haldane and JG Priestley, Respiration, 2nd Ed, Oxford University Press (1935).
• J. S. Haldane, The Philosophy of a Biologist, 2nd Ed, Oxford University Press (1936).

See also

• Decompression (diving) – Pressure reduction and its effects during ascent from depth
• Haldane's decompression model – Decompression model developed by John Scott Haldane

References

1. ^ Douglas, C. G. (1936). "John Scott Haldane. 1860-1936". Obituary Notices of Fellows of the Royal Society. 2 (5): 114–139. doi:10.1098/rsbm.1936.0009. JSTOR 769132.
2. ^ Acott, C. (1999). "JS Haldane, JBS Haldane, L Hill, and A Siebe: A brief resume of their lives". South Pacific Underwater Medicine Society Journal. 29 (3). ISSN 0813-1988. OCLC 16986801. Archived from the original on 27 July 2011. Retrieved 12 July 2008.{{cite journal}}: CS1 maint: unfit URL (link)
3. BBC radio interview, Third Programme, 1960.
4. ^ Lang, Michael A.; Brubakk, Alf O. (13–14 March 2009). Pollock, N.W. (ed.). The Haldane Effect (PDF). Diving for Science 2009. Proceedings of the American Academy of Underwater Sciences 28th Symposium. Sea Grant Publication # CTSG-10-09. Dauphin Island, AL: AAUS. pp. 111–124. ISBN 978-0-9800423-3-7.
5. Goodman, Martin (2007). Suffer and Survive: Gas Attacks, Miners' Canaries, Spacesuits, and the Bends: the Extreme Life of Dr. J.S. Haldane. Simon & Schuster. ISBN 978-0-7432-8597-1.
6. Obituary. Professor J. S. Haldane. dmm.org.uk. 16 March 1936
7. Addison, Henry Robert; Oakes, Charles Henry; Lawson, William John; Sladen, Douglas Brooke Wheelton (1907). "HALDANE, John Scott". Who's Who. 59: 757.
8. Daughter of The Right Hon Richard Keatinge PC KC (1793-1876), a judge of the Irish High Court
9. Calder, Jenni (2019), The Burning Glass: The Life of Naomi Mitchison, Sandstone Press, Dingwall, pp. 5 - 15, ISBN 9781912240661
10. "Makgill, Robert Haldane". teara.govt.nz. January 2012. Retrieved 25 April 2020.
11. "University intelligence". The Times. No. 36588. London. 17 October 1901. p. 4.
12. "Lists of Royal Society Fellows 1660–2007" (PDF). London: The Royal Society. Retrieved 21 July 2010.
13. ^ Sekhar, K.C.; Rao, S.S.C. Chakra (2014). "John Scott Haldane: The father of oxygen therapy". Indian Journal of Anaesthesia. 58 (3): 350–352. doi:10.4103/0019-5049.135087. ISSN 0019-5049. PMC 4091013. PMID 25024490.
14. "John Scott Haldane Prize Lecture - Oxford Talks". talks.ox.ac.uk. Retrieved 3 June 2024.
15. Newbolt, Henry (1939). "A Perpetual Memory". University of Virginia Library. p. 13. Retrieved 3 June 2024.
16. The Sciences and Philosophy: Gifford Lectures, University of Glasgow, 1927–28 by J.S. Haldane, Doubleday, Doran and Co., Inc., Garden City, NY, 1929.
17. "J. S. Haldane". oxonblueplaques.org.uk. Retrieved 3 June 2024.
18. "Blue plaque tribute to scientific pioneer". Oxford Mail. 4 May 2009. Retrieved 3 June 2024.
19. Boycott, A. E.; Damant, G. C. C.; Haldane, J. S. (1908). "Prevention of compressed air illness". J. Hygiene. 8 (3): 342–443. doi:10.1017/S0022172400003399. PMC 2167126. PMID 20474365.
20. Hellemans, Alexander; Bunch, Bryan (1988). The Timetables of Science. Simon & Schuster. p. 411. ISBN 0671621300.
21. US Navy (1 December 2016). U.S. Navy Diving Manual Revision 7 SS521-AG-PRO-010 0910-LP-115-1921 (PDF). Washington, DC.: US Naval Sea Systems Command.
22. "1986: Coal mine canaries made redundant". BBC. 30 December 1986. Retrieved 3 June 2024.
23. Liu, Xiao; Cheng, Sitian; Liu, Hong; Hu, Sha; Zhang, Daqiang; Ning, Huansheng (2012). "A survey on gas sensing technology". Sensors (Basel, Switzerland). 12 (7): 9635–9665. Bibcode:2012Senso..12.9635L. doi:10.3390/s120709635. ISSN 1424-8220. PMC 3444121. PMID 23012563.
24. "Construction of new USARIEM Pikes Peak laboratory begins this summer. 2018". US Army. 22 June 2018. Retrieved 13 March 2019.

Further reading

• Lang, Michael A; Brubakk, Alf O., eds. (2009), The Future of Diving: 100 Years of Haldane and Beyond, Washington, D.C.: Smithsonian Institution Scholarly Press, ISBN 978-0-9788460-5-3
• Haldane, Louisa Kathleen (2009). Mitchison, Naomi (ed.). Friends and Kindred: Memoirs of Louisa Kathleen Haldane. Kennedy & Boyd. ISBN 978-1-904999-99-7.

External links

• Works by or about John Scott Haldane at the Internet Archive
• Biography of John Scott Haldane Archived 23 July 2014 at the Wayback Machine on Gifford Lectures site
• John Scott Haldane Biography on bookrags.com
• Obituary
• Haldane's blue plaque in north Oxford
• Haldane's blood gas analyser
• Decompression theory for goats

• 1860 births
• 1936 deaths
• Alumni of the University of Edinburgh
• Fellows of the Royal Society
• Foreign associates of the National Academy of Sciences
• Haldane family
• High-altitude medicine physicians
• Members of the Order of the Companions of Honour
• People educated at Edinburgh Academy
• People educated at The Dragon School
• Scientists from Edinburgh
• Recipients of the Copley Medal
• Royal Medal winners
• Scottish inventors
• Scottish physiologists
• Scottish scholars and academics
• Coal miner activists
• Scottish activists
• Decompression researchers
• University of Jena alumni
• Medical doctors from Edinburgh