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JNJ-26990990

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Experimental anticonvulsant drug Pharmaceutical compound
JNJ-26990990
Clinical data
Other namesN-((Benzothien-3-yl)methyl)sulfamide
Identifiers
IUPAC name
  • 3--1-benzothiophene
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC9H10N2O2S2
Molar mass242.31 g·mol
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JNJ-26990990 is a broad-spectrum anticonvulsant drug currently under development by Janssen Pharmaceutica as a second-generation follow-up to the marketed drug topiramate. It was designed to have the same anticonvulsant effects as topiramate, but without the side effects associated with topiramate's carbonic anhydrase inhibition. It also has potential use in the treatment of inflammatory pain, neuropathic pain, and depression.

JNJ-26990990 entered phase II clinical trials in October 2007.

Metabolites and radioactive isotope-labeled derivatives of JNJ-26990990 have also been prepared to support its development.

See also

References

  1. ^ Parker MH, Smith-Swintosky VL, McComsey DF, Huang Y, Brenneman D, Klein B, et al. (December 2009). "Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzothien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies". Journal of Medicinal Chemistry. 52 (23): 7528–7536. doi:10.1021/jm801432r. PMID 19388676.
  2. WO patent 2006023861, Parker MH, Reitz AB, Maryanoff BE, "Preparation of benzo-fused heteroaryl sulfamide derivatives for the treatment of epilepsy and related disorders", issued 2006-03-02, assigned to Janssen Pharmaceutica 
  3. "JNJ 26990990 Johnson & Johnson developing anticonvulsant Johnson & Johnson preclinical data". R & D Focus Drug News. September 22, 2008. Archived from the original on October 12, 2012.
  4. Fischer J, Ganellin CR (2010). "Chapter 2. Standalone Drugs". Analogue-Based Drug Discovery II. doi:10.1002/9783527630035.ch2.
  5. Lin R, Weaner LE, Hoerr DC, Salter R, Gong Y (January 2013). "Expeditious syntheses of stable and radioactive isotope-labeled anticonvulsant agent, JNJ-26990990, and its metabolites". Journal of Labelled Compounds & Radiopharmaceuticals. 56 (1): 22–26. doi:10.1002/jlcr.3013. PMID 24285137.
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