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Jean Pieters

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Dutch biochemist
Jean Pieters
Jean Pieters (2015)
NationalityDutch
Scientific career
FieldsBiochemistry
InstitutionsUniversity of Leuven, Maastricht University, European Molecular Biology Laboratory, Netherlands Cancer Institute in Amsterdam, Basel Institute for Immunology, Biozentrum University of Basel

Jean Pieters is a Dutch biochemist and Professor at the Biozentrum of the University of Basel, Switzerland.

Life

Jean Pieters studied biochemistry and microbiology at the University of Leuven in Belgium. After completing his doctorate at Maastricht University, the Netherlands, he joined the European Molecular Biology Laboratory (EMBL) in Heidelberg in 1989 as a postdoctoral fellow in Bernhard Dobberstein’s laboratory. From 1992 until 1995 Jean Pieters researched at the Netherlands Cancer Institute in Amsterdam as a junior group leader. In 1996 he was recruited to the Basel Institute for Immunology and in 2002 appointed to the Biozentrum at the University of Basel.

Work

Jean Pieters investigates the role of coronin proteins in activating cellular signal transduction processes. Coronin proteins are widely distributed in the eukaryotic kingdom and conserved from yeast to man. One of the most conserved members of this protein family, mammalian coronin 1, was originally discovered in his laboratory as a host factor responsible for the intracellular survival of pathogenic mycobacteria. Subsequent work from his laboratory showed that coronin proteins regulate diverse physiologic processes including T cell homeostasis, learning and memory and development. More recently, his laboratory showed that coronin 1 signaling plays a crucial role in auto- and alloimmunity and that coronin-mediated signaling underlies the longevity of T cells. Research in his laboratory currently focusses on the role for coronin proteins in the establishment and regulation of cell populations.

Awards and honors

Notable publications

References

  1. Orcid profile Orcid.org Retrieved 2021-12-13
  2. Ferrari, G.; Langen, H.; Naito, M.; Pieters, Jean (14 May 1999). "A coat protein on phagosomes involved in the intracellular survival of mycobacteria". Cell. 97 (4): 435–447. doi:10.1016/s0092-8674(00)80754-0. PMID 10338208. S2CID 18159353.
  3. Mueller, Philipp; Massner, Jan; Jayachandran, Rajesh; Combaluzier, Benoit; Albrecht, Imke; Gatfield, John; Blum, Carmen; Ceredig, Rod; Rodewald, Hans-Reimer; Rolink, Antonius G; Pieters, Jean (April 2008). "Regulation of T cell survival through coronin-1-mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering". Nat Immunol. 9 (4): 424–31. doi:10.1038/ni1570. PMID 18345003. S2CID 26849229.
  4. Jayachandran, Rajesh; Liu, Xiaolong; Bosedasgupta, Somdeb; Müller, Philipp; Zhang, Chun-Lei; Moshous, Despina; Studer, Vera; Schneider, Jacques; Genoud, Christel; Fossoud, Catherine; Gambino, Frédéric; Khelfaoui, Malik; Müller, Christian; Bartholdi, Deborah; Rossez, Helene; Stiess, Michael; Houbaert, Xander; Jaussi, Rolf; Frey, Daniel; Kammerer, Richard A; Deupi, Xavier; de Villartay, Jean-Pierre; Lüthi, Andreas; Humeau, Yann; Pieters, Jean (25 March 2014). "Coronin 1 regulates cognition and behavior through modulation of cAMP/protein kinase A signaling". PLOS Biol. 12 (3): e1001820. doi:10.1371/journal.pbio.1001820. PMC 3965382. PMID 24667537.
  5. Vinet, Adrien F; Fiedler, Thomas; Studer, Vera; Froquet, Romain; Dardel, Anna; Cosson, Pierre; Pieters, Jean (25 March 2014). "Initiation of multicellular differentiation in Dictyostelium discoideum is regulated by coronin A". Mol Biol Cell. 25 (5): 688–701. doi:10.1091/mbc.E13-04-0219. PMC 3937094. PMID 24403600.
  6. Pieters, Jean; Müller, Philipp; Jayachandran, Rajesh (13 July 2013). "On guard: coronin proteins in innate and adaptive immunity". Nat Rev Immunol. 13 (7): 510–518. doi:10.1038/nri3465. PMID 23765056. S2CID 38179365.
  7. Jayachandran, Rajesh; Gumienny, Aleksandra; Bolinger, Beatrice; Ruehl, Sebastian; Lang, Mathias Jakob; Fucile, Geoffrey; Mazumder, Saumyabrata; Tchang, Vincent; Woischnig, Anne-Kathrin; Stiess, Michael; Kunz, Gabriele; Claudi, Beatrice; Schmaler, Mathias; Siegmund, Kerstin; Li, Jianping; Dertschnig, Simone; Holländer, George; Medina, Eva; Karrer, Urs; Moshous, Despina; Bumann, Dirk; Khanna, Nina; Rossi, Simona W; Pieters, Jean (15 January 2019). "Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity". Immunity. 50 (1): 152–165.e8. doi:10.1016/j.immuni.2018.12.011. hdl:10033/622367. PMID 30611611. S2CID 58669087.
  8. Ford, Mandy L (15 January 2019). "Coronin-1, King of Alloimmunity". Immunity. 50 (1): 3–5. doi:10.1016/j.immuni.2018.12.030. PMID 30650379. S2CID 58571940.
  9. Mori, Mayumi; Ruer-Laventie, Julie; Duchemin, Wandrille; Demougin, Philippe; Ndinyanka Fabrice, Tohnyui; Wymann, Matthias P; Pieters, Jean (21 December 2021). "Suppression of caspase 8 activity by a coronin 1-PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling". Sci Signal. 14 (714): eabj0057. doi:10.1126/scisignal.abj0057. PMID 34932374. S2CID 245409202.
  10. Elected Corresponding Member of the Royal Netherlands Academy of Arts and Sciences Archived 2017-02-22 at the Wayback Machine knaw.nl. Retrieved 2014-09-10.
  11. "Jean Pieters". Royal Netherlands Academy of Arts and Sciences. Archived from the original on 30 July 2020.
  12. The Awardees of the Friedrich Miescher-Award Archived 2013-10-29 at the Wayback Machine swissbiochem.ch. Retrieved 2014-09-10.
  13. Pfizer Forschungspreis, Preisträger 2001 Archived 2010-01-30 at the Wayback Machine pfizerforschungspreis.ch. Retrieved 2014-09-10.
  14. Eppendorf Award for Young European Investigators, Past Award Winners Archived 2017-12-29 at the Wayback Machine corporate.eppendorf.com Retrieved 2021-12-13.

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