Jesús Rubio may refer to:
- Jesús Rubio (footballer, born 1994), Andorran football player
- Jesús Rubio (footballer, born 1996), Mexican football player
- Jesús Alberto Rubio (born 1992), Spanish cyclist
- Jesús González Rubio (died 1874), Mexican musician
- Jesús Rubio (footballer, born 1987), Spanish football player
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