John Clay may refer to:
- John Clay (Wars of the Roses), English soldier
- John Clay (chaplain) (1796–1858), English prison chaplain
- John Clay (cricketer, born 1924) (1924–2011), English cricketer
- John Clay (offensive tackle) (born 1964), American football player
- John Clay (running back) (born 1988), American football player
- John Cecil Clay (1875–1930), American illustrator
- John Granby Clay (1766–1846), British general
- John Morrison Clay (1821–1887), American horse breeder
- John P. Clay (1934–2013), investment banker and founder of the Clay Sanskrit Library
- John Randolph Clay (1808–1885), American diplomat
- Johnnie Clay (1898–1973), English cricketer
- The Red-Headed League, an 1891 short story by Arthur Conan Doyle with a character named John Clay
See also
- Jon Clay (born 1963), British former track and road racing cyclist
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