John O'Farrell may refer to:
- John O'Farrell (author) (born 1962), British author, broadcaster and politician
- John O'Farrell (politician) (1826–1892), Canadian politician
- John O'Farrell (venture capitalist), Irish American venture capitalist
- John A. O'Farrell (1823–1900), Irish American adventurer, miner
See also
- J. T. O'Farrell (died 1971), Irish politician and trade union official
- John Farrell (disambiguation)
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