José Vega may refer to:
- José Vega (politician), Peruvian politician
- Jose Vega (fighter) (born 1985), American mixed martial artist
- José Vega (Spanish footballer) (born 1981), Spanish footballer
- José Vega (Ecuadorian footballer)
- José Vega Santana (born 1958), Puerto Rican clown, also known as "Remi"
- José Antonio Rodríguez Vega (1957–2002), Spanish serial killer
- José Chico Vega, Puerto Rican New Progressive Party politician
- José G. Tormos Vega (born 1925), Puerto Rican politician
- José Luis Vega (born 1948), Puerto Rican poet
- Joseph de la Vega (1650–1692), Spanish-Dutch merchant
- Cheo Feliciano (1935–2014), artist name of Puerto Rican composer and singer Jose Luis Feliciano Vega
- Sergio Vega (singer) (1969–2010), stage name of Mexican banda singer José Sergio Vega Cuamea
- José Vega (cyclist) (born 1987), professional road racing cyclist from Costa Rica
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