Juan Romero is the name of:
- Juan Romero (bullfighter), Spanish bullfighter
- Juan Romero (judoka) (born 1988), Uruguayan judoka
- Juan Carlos Romero (politician) (born 1950), Argentine Justicialist Party politician
- Juan Carlos Romero (athlete) (born 1977), Mexican long-distance runner
- Juan Romero (1950–2018), subject of a photograph as the last person to shake Robert F. Kennedy's hand before he was assassinated in 1968
- Juan Carlos Romero (sport shooter) (born 1963), Guatemalan sport shooter
- Juan Pablo Romero (born 1990), Mexican boxer
- the subject of "The Transition of Juan Romero", a 1910 short story by American horror fiction writer H. P. Lovecraft
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