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K+-transporting ATPase

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Class of enzymes
potassium-transporting ATPase
Identifiers
EC no.3.6.3.12
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

In enzymology, a K-transporting ATPase (EC 3.6.3.12) is an enzyme that catalyzes the chemical reaction

ATP + H2O + Kout ⇌ ADP + phosphate + Kin

The 3 substrates of this enzyme are ATP, H2O, and K, whereas its 3 products are ADP, phosphate, and K+.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (K-importing). Other names in common use include K-translocating Kdp-ATPase, and multi-subunit K-transport ATPase. This enzyme participates in two-component system - general.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1SVJ, 1U7Q, 2A00, and 2A29.

References

Hydrolases: acid anhydride hydrolases (EC 3.6)
3.6.1
3.6.2
3.6.3-4: ATPase
3.6.3
Cu++ (3.6.3.4)
Ca+ (3.6.3.8)
Na+/K+ (3.6.3.9)
H+/K+ (3.6.3.10)
Other P-type ATPase
3.6.4
3.6.5: GTPase
3.6.5.1: Heterotrimeric G protein
3.6.5.2: Small GTPase > Ras superfamily
3.6.5.3: Protein-synthesizing GTPase
3.6.5.5-6: Polymerization motors
Enzymes
Activity
Regulation
Classification
Kinetics
Types
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