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KDM4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4LXL, 4UC4
Identifiers
Aliases	KDM4B, JMJD2B, TDRD14B, lysine demethylase 4B, MRD65
External IDs	OMIM: 609765; MGI: 2442355; HomoloGene: 27773; GeneCards: KDM4B; OMA:KDM4B - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.3 Start 4,969,113 bp End 5,153,598 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 D Start 56,633,062 bp End 56,709,870 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in dorsal motor nucleus of vagus nerve corpus epididymis blood caput epididymis inferior olivary nucleus sural nerve parotid gland tendon of biceps brachii nipple Skeletal muscle tissue of biceps brachii Top expressed in Rostral migratory stream lip neural layer of retina superior frontal gyrus otic vesicle primary visual cortex external carotid artery dentate gyrus of hippocampal formation granule cell granulocyte muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity dioxygenase activity metal ion binding histone demethylase activity histone H3-methyl-lysine-36 demethylase activity histone H3-methyl-lysine-9 demethylase activity DNA-binding transcription repressor activity, RNA polymerase II-specific chromatin binding methylated histone binding Cellular component nucleoplasm nucleus histone methyltransferase complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated histone H3-K36 demethylation histone H3-K9 demethylation chromatin organization negative regulation of transcription by RNA polymerase II chromatin remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23030 193796 Ensembl ENSG00000127663 ENSMUSG00000024201 UniProt O94953 Q91VY5 RefSeq (mRNA) NM_015015 NM_001370093 NM_001370094 NM_172132 NM_001357909 RefSeq (protein) NP_055830 NP_001357022 NP_001357023 NP_742144 NP_001344838 Location (UCSC) Chr 19: 4.97 – 5.15 Mb Chr 17: 56.63 – 56.71 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Lysine-specific demethylase 4B is an enzyme that in humans is encoded by the KDM4B gene. KDM4B belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000127663 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000024201 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
6. Katoh M, Katoh M (May 2004). "Identification and characterization of JMJD2 family genes in silico". Int J Oncol. 24 (6): 1623–8. doi:10.3892/ijo.25.3.759. PMID 15138608.
7. "Entrez Gene: JMJD2B jumonji domain containing 2B".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gray SG, Iglesias AH, Lizcano F, et al. (2005). "Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein". J. Biol. Chem. 280 (31): 28507–18. doi:10.1074/jbc.M413687200. PMID 15927959.
• Whetstine JR, Nottke A, Lan F, et al. (2006). "Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases". Cell. 125 (3): 467–81. doi:10.1016/j.cell.2006.03.028. PMID 16603238. S2CID 14461740.
• Katoh Y, Katoh M (2007). "Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells". Int. J. Mol. Med. 20 (2): 269–73. doi:10.3892/ijmm.20.2.269. PMID 17611647.
• Deng P, Yuan Q, Cheng Y, et al. (2021). "Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging". Cell Stem Cell. 28 (6): 1057–1073.e7. doi:10.1016/j.stem.2021.01.010. PMC 8178178. PMID 33571444.

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