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KDM4D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DXT, 3DXU, 4D6Q, 4D6R, 4D6S, 4HON, 4HOO, 5FP9, 5F5A, 5FP8, 5FPA, 5FPB, 5FP4, 5F5C
Identifiers
Aliases	KDM4D, JMJD2D, lysine demethylase 4D
External IDs	OMIM: 609766; MGI: 3606484; HomoloGene: 69244; GeneCards: KDM4D; OMA:KDM4D - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q21 Start 94,973,709 bp End 94,999,519 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A1- A2 Start 14,373,844 bp End 14,411,778 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell left testis right testis testicle gonad sperm secondary oocyte ventricular zone islet of Langerhans stromal cell of endometrium Top expressed in spermatocyte seminiferous tubule spermatid lumbar spinal ganglion embryo lumbar subsegment of spinal cord facial motor nucleus primary visual cortex superior frontal gyrus neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity dioxygenase activity metal ion binding histone demethylase activity histone H3-methyl-lysine-9 demethylase activity DNA-binding transcription repressor activity, RNA polymerase II-specific chromatin binding damaged DNA binding chromatin DNA binding methylated histone binding Cellular component blood microparticle nucleus nucleoplasm site of double-strand break pericentric heterochromatin histone methyltransferase complex Biological process regulation of protein phosphorylation cellular response to ionizing radiation regulation of transcription, DNA-templated positive regulation of chromatin binding double-strand break repair via homologous recombination transcription, DNA-templated positive regulation of double-strand break repair via nonhomologous end joining histone H3-K9 demethylation negative regulation of transcription by RNA polymerase II chromatin organization cellular response to DNA damage stimulus negative regulation of histone H3-K9 trimethylation chromatin remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55693 244694 Ensembl ENSG00000186280 ENSMUSG00000053914 UniProt Q6B0I6 Q3U2K5 RefSeq (mRNA) NM_018039 NM_173433 RefSeq (protein) NP_060509 NP_775609 Location (UCSC) Chr 11: 94.97 – 95 Mb Chr 9: 14.37 – 14.41 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Lysine-specific demethylase 4D is an enzyme that in humans is encoded by the KDM4D gene. KDM4D belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

In 2017, messenger RNA from this gene was used in the somatic cell nuclear transfer experiment that produced the first two cloned primates from post-embryonic donor material. A similar experiment was carried out to increase the cloning efficiency of bovine species in 2018.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000186280 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000053914 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Katoh M, Katoh M (June 2004). "Identification and characterization of JMJD2 family genes in silico". International Journal of Oncology. 24 (6): 1623–8. doi:10.3892/ijo.25.3.759. PMID 15138608.
6. "Entrez Gene: JMJD2D jumonji domain containing 2D".
7. Liu Z, Cai Y, Wang Y, Nie Y, Zhang C, Xu Y, Zhang X, Lu Y, Wang Z, Poo M, Sun Q (February 2018). "Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer". Cell. 172 (4): 881–887.e7. doi:10.1016/j.cell.2018.01.020. PMID 29395327.
8. Stein R (24 January 2018). "Chinese Scientists Clone Monkeys Using Method That Created Dolly The Sheep". National Public Radio. Retrieved 24 January 2018.
9. Liu X, Wang Y, Gao Y, Su J, Zhang J, Xing X, Zhou C, Yao K, An Q, Zhang Y (February 2018). "H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming". Development. 145 (4): dev158261. doi:10.1242/dev.158261. PMID 29453221.

Further reading

• Shin S, Janknecht R (August 2007). "Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D". Biochemical and Biophysical Research Communications. 359 (3): 742–6. doi:10.1016/j.bbrc.2007.05.179. PMID 17555712.
• Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y (May 2006). "Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases". Cell. 125 (3): 467–81. doi:10.1016/j.cell.2006.03.028. PMID 16603238. S2CID 14461740.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

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