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KIAA1967

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Protein-coding gene in the species Homo sapiens Not to be confused with Deleted in Bladder Cancer 1 (DBC1).
CCAR2
Identifiers
AliasesCCAR2, DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC, cell cycle and apoptosis regulator 2
External IDsOMIM: 607359; MGI: 2444228; HomoloGene: 10910; GeneCards: CCAR2; OMA:CCAR2 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)
Chromosome 8 (human)Genomic location for CCAR2Genomic location for CCAR2
Band8p21.3Start22,604,757 bp
End22,620,964 bp
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)
Chromosome 14 (mouse)Genomic location for CCAR2Genomic location for CCAR2
Band14|14 D2Start70,375,613 bp
End70,391,260 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • ganglionic eminence

  • right uterine tube

  • right testis

  • left testis

  • granulocyte

  • skin of leg

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • appendix
Top expressed in
  • ventricular zone

  • spermatocyte

  • neural layer of retina

  • dentate gyrus of hippocampal formation granule cell

  • renal corpuscle

  • medullary collecting duct

  • neural tube

  • ganglionic eminence

  • superior frontal gyrus

  • primary visual cortex
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57805

219158

Ensembl

ENSG00000158941

ENSMUSG00000033712

UniProt

Q8N163

Q8VDP4

RefSeq (mRNA)

NM_021174
NM_199205
NM_001363068
NM_001363069
NM_001393997

NM_146055

RefSeq (protein)

NP_066997
NP_001349997
NP_001349998

NP_666167

Location (UCSC)Chr 8: 22.6 – 22.62 MbChr 14: 70.38 – 70.39 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

KIAA1967, also known as Deleted in Breast Cancer 1, is a protein which in humans is encoded by the KIAA1967 gene.

Function

Recent studies show that DBC1 is an inhibitor of the sirtuin-type deacetylase, SIRT1, which deacetylates histones and p53. DBC1 is likely to regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000158941Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000033712Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: KIAA1967 KIAA1967".
  6. Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
  7. Hamaguchi M, Meth JL, von Klitzing C, Wei W, Esposito D, Rodgers L, Walsh T, Welcsh P, King MC, Wigler MH (October 2002). "DBC2, a candidate for a tumor suppressor gene involved in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13647–52. Bibcode:2002PNAS...9913647H. doi:10.1073/pnas.212516099. PMC 129730. PMID 12370419.
  8. Kim JE, Chen J, Lou Z (January 2008). "DBC1 is a negative regulator of SIRT1". Nature. 451 (7178): 583–6. Bibcode:2008Natur.451..583K. doi:10.1038/nature06500. PMID 18235501. S2CID 4420753.
  9. Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W (January 2008). "Negative regulation of the deacetylase SIRT1 by DBC1". Nature. 451 (7178): 587–90. Bibcode:2008Natur.451..587Z. doi:10.1038/nature06515. PMC 2866287. PMID 18235502.
  10. Anantharaman V, Aravind L (May 2008). "Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of Sirtuin domain deacetylases by NAD metabolites". Cell Cycle. 7 (10): 1467–72. doi:10.4161/cc.7.10.5883. PMC 2423810. PMID 18418069.

Further reading

KIAA human genes


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