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KLHL7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3II7
Identifiers
Aliases	KLHL7, KLHL6, SBBI26, kelch like family member 7, CISS3, PERCHING
External IDs	OMIM: 611119; MGI: 1196453; HomoloGene: 10317; GeneCards: KLHL7; OMA:KLHL7 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p15.3 Start 23,105,758 bp End 23,177,914 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 A3|5 10.67 cM Start 24,305,603 bp End 24,365,790 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte right ventricle sperm ganglionic eminence left testis right testis lateral nuclear group of thalamus ventricular zone myocardium of left ventricle Top expressed in ganglionic eminence medial ganglionic eminence ventricular zone superior cervical ganglion islet of Langerhans ventromedial nucleus Epithelium of choroid plexus sternocleidomastoid muscle nucleus accumbens myocardium of ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein homodimerization activity identical protein binding ubiquitin-protein transferase activity Cellular component plasma membrane nucleolus nucleoplasm nucleus Cul3-RING ubiquitin ligase complex cytoplasm cytosol perinuclear region of cytoplasm Biological process protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55975 52323 Ensembl ENSG00000122550 ENSMUSG00000028986 UniProt Q8IXQ5 Q8BUL5 RefSeq (mRNA) NM_001031710 NM_001172428 NM_018846 NM_001161800 NM_026448 RefSeq (protein) NP_001026880 NP_001165899 NP_061334 NP_001155272 NP_080724 Location (UCSC) Chr 7: 23.11 – 23.18 Mb Chr 5: 24.31 – 24.37 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Kelch-like protein 7 is a protein that in humans is encoded by the KLHL7 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000122550 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028986 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Friedman JS, Ray JW, Waseem N, Johnson K, Brooks MJ, Hugosson T, Breuer D, Branham KE, Krauth DS, Bowne SJ, Sullivan LS, Ponjavic V, Granse L, Khanna R, Trager EH, Gieser LM, Hughbanks-Wheaton D, Cojocaru RI, Ghiasvand NM, Chakarova CF, Abrahamson M, Goring HH, Webster AR, Birch DG, Abecasis GR, Fann Y, Bhattacharya SS, Daiger SP, Heckenlively JR, Andreasson S, Swaroop A (Jun 2009). "Mutations in a BTB-Kelch Protein, KLHL7, Cause Autosomal-Dominant Retinitis Pigmentosa". Am J Hum Genet. 84 (6): 792–800. doi:10.1016/j.ajhg.2009.05.007. PMC 2694974. PMID 19520207.
6. "Entrez Gene: KLHL7 kelch-like 7 (Drosophila)".

Further reading

• Bredholt G, Storstein A, Haugen M, et al. (2006). "Detection of autoantibodies to the BTB-kelch protein KLHL7 in cancer sera". Scand. J. Immunol. 64 (3): 325–35. doi:10.1111/j.1365-3083.2006.01821.x. PMID 16918702. S2CID 27686744.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.

External links

• GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview

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• Kelch proteins