KPC may refer to:
- kiloparsec (kpc), a unit of measurement used in astronomy
- Kaltim Prima Coal, a thermal coal mine in Kalimantan Timur, Indonesia
- Kampala Pentecostal Church, an English speaking church in downtown Kampala, Uganda
- King's Privy Council for Canada, an advisory body to the monarch of Canada
- Kenai Peninsula College, a college with three campuses on the Kenai Peninsula in Alaska
- Key purchasing criteria, a business term defining factors that contribute to a consumer's buying decision
- KPC Media Group, a media company based in Kendallville, Indiana
- Kenya Pipeline Company, a state corporation of Kenya
- Kiribati Protestant Church, the former name of the Kiribati Uniting Church, the second-largest religious group in Kiribati
- Klebsiella pneumoniae carbapenemase, the gene for an enzyme produced by some highly antibiotic-resistant bacteria
- Kosovo Protection Corps
- Kuwait Petroleum Corporation, an umbrella company which takes control of all petroleum and oil-related aspects of Kuwait
- Kunzang Palyul Choling, a Tibetan Buddhist organization headed by Jetsunma Ahkon Lhamo
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