Kafue may refer to:
- Kafue River, a major river Zambia, tributary of the Zambezi
- Kafue, A town in the Lusaka Province of Zambia
- Kafue District, A district in the Lusaka Province of Zambia
- Kafue (constituency), a parliamentary constituency in Zambia
- Kafue National Park, The largest National Park in Zambia
- Kafue Flats, a flood plain in Zambia
- Kafue Gorge Dam, A dam in Zambia
- Kafue Gorge Lower Power Station, A hydroelectric power station in Zambia
- Kafue Gorge Upper Power Station, A hydroelectric power station in Zambia
- Kafue Railway Bridge, A railway bridge across the Kafue River
- Kafue lechwe, a species of lechwe
- Kafue mole-rat, a species of rodent in the family Bathyergidae
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