Kgositsile is a surname. Notable people with the surname include:
- Baleka Mbete-Kgositsile (born 1949), South African politician
- Keorapetse Kgositsile (1938–2018), South African poet and political activist
- Melba Johnson Kgositsile (1940–1994), American civil rights activist
- Thebe Neruda Kgositsile (born 1994), American rapper and record producer
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