Klossowski (feminine: Klossowska) is a Polish surname, and may refer to:
- Baladine Klossowska
- Balthazar Klossowski de Rola, the French painter Balthus
- Erich Klossowski
- Madame Klossowski, Loulou de la Falaise - ex-wife of Thadée Klossowski de Rola, the youngest son of Balthus
- Pierre Klossowski
- Setsuko Klossowska de Rola
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