Klug is a surname. Notable people with the surname include:
- Johann Christoph Friedrich Klug (1775–1856), German entomologist
- Bernd Klug (1914–1975), German naval officer
- Al Klug (1920–1957), American football player
- Aaron Klug (1926–2018), Lithuanian-born chemist
- Brian Klug (fl. late 20th century), academic in U.K.
- Howard Klug (fl. c. 2000), American clarinetist & academic
- Scott L. Klug (born 1953), American politician
- Bryan Klug (born 1960), English footballer
- John Klug (born 1965), Australian footballer
- Gerald Klug (born 1968), Austrian politician
- Chris Klug (born 1972), American snowboarder
- Gerard Christopher Klug, American game designer
- Yolanda Klug (born 1995/1996), missing German who disappeared in 2019
- Joel Klug, American reality show contestant
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