Kunene or Cunene may refer to:
Geography
- Kunene River (also spelled Cunene), Angola and Namibia
- Kunene Region, Namibia
- Cunene Province, Angola
People
- Daniel Kunene (1923–2016), South African literary scholar, translator and writer
- Dominic Kunene, Liswati football manager
- Kenny Kunene (born 1970), South African businessman
- Manqoba Kunene (born 1982), Liswati footballer
- Madala Kunene (born 1947), South African musician
- Mazisi Kunene (1930–2006), South African poet and historian
- Ntandoyenkosi Kunene, South African beauty pagent contestant
- Victor Kunene (born 1966), South African boxer
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