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KCND3

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(Redirected from Kv4.3) Protein-coding gene in the species Homo sapiens
KCND3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1S1G, 2NZ0

Identifiers
AliasesKCND3, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22, BRGDA9, potassium voltage-gated channel subfamily D member 3
External IDsOMIM: 605411; MGI: 1928743; HomoloGene: 21036; GeneCards: KCND3; OMA:KCND3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)
Chromosome 1 (human)Genomic location for KCND3Genomic location for KCND3
Band1p13.2Start111,770,662 bp
End111,989,668 bp
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)
Chromosome 3 (mouse)Genomic location for KCND3Genomic location for KCND3
Band3|3 F2.2Start105,359,646 bp
End105,581,318 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar vermis

  • pars reticulata

  • lateral nuclear group of thalamus

  • pars compacta

  • paraflocculus of cerebellum

  • Brodmann area 23

  • middle temporal gyrus

  • tail of epididymis

  • Parietal Lobe

  • caput epididymis
Top expressed in
  • substantia nigra

  • ventral tegmental area

  • lateral geniculate nucleus

  • medial geniculate nucleus

  • habenula

  • vas deferens

  • anterior amygdaloid area

  • subiculum

  • pineal gland

  • supraoptic nucleus
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3752

56543

Ensembl

ENSG00000171385

ENSMUSG00000040896

UniProt

Q9UK17

Q9Z0V1

RefSeq (mRNA)

NM_004980
NM_172198
NM_001378969
NM_001378970

NM_001039347
NM_019931

RefSeq (protein)

NP_004971
NP_751948
NP_001365898
NP_001365899

NP_001034436
NP_064315

Location (UCSC)Chr 1: 111.77 – 111.99 MbChr 3: 105.36 – 105.58 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Potassium voltage-gated channel subfamily D member 3 also known as Kv4.3 is a protein that in humans is encoded by the KCND3 gene. It contributes to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.

Function

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes – shaker, shaw, shab, and shal – have been identified in Drosophila, and each has been shown to have human homolog(s).

Kv4.3 is a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene.

Clinical significance

Gain of function is believed to cause Brugada syndrome although only indirectly shown by mutations in the beta subunit KCNE3 which causes gain of function of Kv4.3.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000171385Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000040896Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Postma AV, Bezzina CR, de Vries JF, Wilde AA, Moorman AF, Mannens MM (Aug 2000). "Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3". Hum Genet. 106 (6): 614–9. doi:10.1007/s004390050033. PMID 10942109.
  6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
  7. ^ "Entrez Gene: KCND3 potassium voltage-gated channel, Shal-related subfamily, member 3".
  8. Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". J. Mol. Cell. Cardiol. 33 (5): 851–72. doi:10.1006/jmcc.2001.1376. PMID 11343410.

Further reading

External links


PDB gallery
  • 1s1g: Crystal Structure of Kv4.3 T1 Domain 1s1g: Crystal Structure of Kv4.3 T1 Domain
  • 2i2r: Crystal structure of the KChIP1/Kv4.3 T1 complex 2i2r: Crystal structure of the KChIP1/Kv4.3 T1 complex
  • 2nz0: Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 (CASP Target) 2nz0: Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 (CASP Target)
Membrane transport protein: ion channels (TC 1A)
Ca: Calcium channel
Ligand-gated
Voltage-gated
Na: Sodium channel
Constitutively active
Proton-gated
Voltage-gated
K: Potassium channel
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl: Chloride channel
H: Proton channel
M: CNG cation channel
M: TRP cation channel
H2O (+ solutes): Porin
Cytoplasm: Gap junction
By gating mechanism
Ion channel class
see also disorders

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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