Kynapcin is a general name for a number of dibenzofuranyl derivatives of the molecule polyozellin, present in the fungus Polyozellus multiplex. Like polyozellin, some kynapcins inhibit prolyl endopeptidase, an enzyme that has a role in processing proteins including amyloid precursor protein. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects. Several kynapcins have been found in P. multiplex, each with different chemical properties, including kynapcin-12, kynapcin-13 and -28, and -24. A total synthesis of kynapcin-24 was achieved in 2009.
References
- Hwang JS, Song KS, Kim WG, Lee TH, Koshino H, Yoo ID (1997). "Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiplex". The Journal of Antibiotics. 50 (9): 773–777. doi:10.7164/antibiotics.50.773. PMID 9360624.
- Lee HJ, Rhee IK, Lee KB, Yoo ID, Song KS (2000). "Kynapcin-12, a new p-terphenyl derivative from Polyozellus multiplex, inhibits prolyl endopeptidase". The Journal of Antibiotics. 53 (7): 714–719. doi:10.7164/antibiotics.53.714. PMID 10994814.
- Kim SI, Park IH, Song KS (2002). "kynapcin-13 and -28, new benzofuran prolyl endopeptidase inhibitors from Polyozellus multiplex". The Journal of Antibiotics. 55 (7): 623–628. doi:10.7164/antibiotics.55.623. PMID 12243451.
- Song KS, Raskin I (2002). "A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex". Journal of Natural Products. 65 (1): 76–78. doi:10.1021/np010194b. PMID 11809072.
- Yang LY, Chang CF, Huang YC, Lee YJ, Hu CC, Tseng TH (2009). "The first total synthesis of kynapcin-24 by palladium catalysis". Synthesis. 2009 (7): 1175–1179. doi:10.1055/s-0028-1087998.
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