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LAD1
Identifiers
Aliases	LAD1, LadA, ladinin 1
External IDs	OMIM: 602314; MGI: 109343; HomoloGene: 4059; GeneCards: LAD1; OMA:LAD1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q32.1 Start 201,380,833 bp End 201,399,915 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 E4 Start 135,746,336 bp End 135,761,080 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg mucosa of transverse colon gallbladder mucosa of ileum gums gingival epithelium rectum epithelium of colon mucosa of pharynx Top expressed in esophagus lip ileum transitional epithelium of urinary bladder epithelium of stomach large intestine left colon duodenum skin of abdomen crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cadherin binding structural molecule activity Cellular component extracellular exosome extracellular region basement membrane actin cytoskeleton Biological process cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3898 16763 Ensembl ENSG00000159166 ENSMUSG00000041782 UniProt O00515 P57016 RefSeq (mRNA) NM_005558 NM_133664 RefSeq (protein) NP_005549 NP_598425 Location (UCSC) Chr 1: 201.38 – 201.4 Mb Chr 1: 135.75 – 135.76 Mb PubMed search
Wikidata
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Ladinin-1 is a protein that in humans is encoded by the LAD1 gene.

The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000159166 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000041782 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Marinkovich MP, Taylor TB, Keene DR, Burgeson RE, Zone JJ (Jun 1996). "LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel 120-kDa anchoring filament protein synthesized by epidermal cells". J Invest Dermatol. 106 (4): 734–8. doi:10.1111/1523-1747.ep12345782. PMID 8618013.
6. Motoki K, Megahed M, LaForgia S, Uitto J (Apr 1997). "Cloning and chromosomal mapping of mouse ladinin, a novel basement membrane zone component". Genomics. 39 (3): 323–30. doi:10.1006/geno.1996.4507. PMID 9119369.
7. ^ "Entrez Gene: LAD1 ladinin 1".

Further reading

• Uitto J, Pulkkinen L (1997). "Molecular complexity of the cutaneous basement membrane zone". Mol. Biol. Rep. 23 (1): 35–46. doi:10.1007/BF00357071. PMID 8983017. S2CID 23991264.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.{{cite journal}}: CS1 maint: numeric names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shimizu H, Takizawa Y, Pulkkinen L, et al. (1998). "The 97 kDa linear IgA bullous dermatosis antigen is not expressed in a patient with generalized atrophic benign epidermolysis bullosa with a novel homozygous G258X mutation in COL17A1". J. Invest. Dermatol. 111 (5): 887–92. doi:10.1046/j.1523-1747.1998.00363.x. PMID 9804354.
• Ishiko A, Shimizu H, Masunaga T, et al. (1998). "97 kDa linear IgA bullous dermatosis antigen localizes in the lamina lucida between the NC16A and carboxyl terminal domains of the 180 kDa bullous pemphigoid antigen". J. Invest. Dermatol. 111 (1): 93–6. doi:10.1046/j.1523-1747.1998.00231.x. PMID 9665393.
• Ishiko A, Shimizu H, Masunaga T, et al. (1996). "97-kDa linear IgA bullous dermatosis (LAD) antigen localizes to the lamina lucida of the epidermal basement membrane". J. Invest. Dermatol. 106 (4): 739–43. doi:10.1111/1523-1747.ep12345793. PMID 8618014.

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