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LIMS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IXE
Identifiers
Aliases	LIMS2, PINCH-2, PINCH2, LGMD2W, LIM zinc finger domain containing 2, MDRCMTT
External IDs	OMIM: 607908; MGI: 2385067; HomoloGene: 41214; GeneCards: LIMS2; OMA:LIMS2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q14.3 Start 127,638,381 bp End 127,681,786 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 B1 Start 32,055,343 bp End 32,091,672 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle layer of sigmoid colon body of uterus right coronary artery popliteal artery tibial arteries ascending aorta Descending thoracic aorta left coronary artery right lung Top expressed in tunica media of zone of aorta interventricular septum ascending aorta right lung lobe sciatic nerve left lobe of liver umbilical cord spermatocyte aortic valve myocardium of ventricle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding Cellular component cytosol cell junction plasma membrane membrane nucleus focal adhesion cytoplasm cell-cell junction Biological process positive regulation of integrin-mediated signaling pathway negative regulation of neural precursor cell proliferation cell-cell junction organization negative regulation of apoptotic process negative regulation of hepatocyte proliferation cell junction assembly negative regulation of epithelial cell proliferation cell-cell adhesion positive regulation of substrate adhesion-dependent cell spreading Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55679 225341 Ensembl ENSG00000072163 ENSMUSG00000024395 UniProt Q7Z4I7 Q91XD2 RefSeq (mRNA) NM_001136037 NM_001161403 NM_001161404 NM_001256542 NM_017980 NM_144862 NM_001365015 NM_001379137 NM_001379138 RefSeq (protein) NP_001129509 NP_001154875 NP_001154876 NP_001243471 NP_060450 NP_659111 NP_001351944 NP_001366066 NP_001366067 Location (UCSC) Chr 2: 127.64 – 127.68 Mb Chr 18: 32.06 – 32.09 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

LIM zinc finger domain containing 2 is a protein that in humans is encoded by the LIMS2 gene.

Function

This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. .

References

1. ^ GRCh38: Ensembl release 89: ENSG00000072163 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000024395 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: LIM zinc finger domain containing 2". Retrieved 2017-11-06.

Further reading

• Zhang Y, Chen K, Guo L, Wu C (2002). "Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration". J. Biol. Chem. 277 (41): 38328–38. doi:10.1074/jbc.M205576200. PMID 12167643.
• Kim SK, Jang HR, Kim JH, Noh SM, Song KS, Kim MR, Kim SY, Yeom YI, Kim NS, Yoo HS, Kim YS (2006). "The epigenetic silencing of LIMS2 in gastric cancer and its inhibitory effect on cell migration". Biochem. Biophys. Res. Commun. 349 (3): 1032–40. doi:10.1016/j.bbrc.2006.08.128. PMID 16959213.
• Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
• Yuan Y, Dong HP, Nymoen DA, Nesland JM, Wu C, Davidson B (2011). "PINCH-2 expression in cancers involving serosal effusions using quantitative PCR". Cytopathology. 22 (1): 22–9. doi:10.1111/j.1365-2303.2010.00757.x. PMC 3225403. PMID 20500520.
• Park CH, Rha SY, Ahn JB, Shin SJ, Kwon WS, Kim TS, An S, Kim NK, Yang WI, Chung HC (2015). "PINCH-2 presents functional copy number variation and suppresses migration of colon cancer cells by paracrine activity". Int. J. Cancer. 136 (10): 2273–83. doi:10.1002/ijc.29273. PMID 25346044. S2CID 2850271.
• Chardon JW, Smith AC, Woulfe J, Pena E, Rakhra K, Dennie C, Beaulieu C, Huang L, Schwartzentruber J, Hawkins C, Harms MB, Dojeiji S, Zhang M, Majewski J, Bulman DE, Boycott KM, Dyment DA (2015). "LIMS2 mutations are associated with a novel muscular dystrophy, severe cardiomyopathy and triangular tongues". Clin. Genet. 88 (6): 558–64. doi:10.1111/cge.12561. PMID 25589244. S2CID 23714774.

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