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LIN28B (gene)

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Protein-coding gene in the species Homo sapiens
LIN28B
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4A4I

Identifiers
AliasesLIN28B, CSDD2, lin-28 homolog B
External IDsOMIM: 611044; MGI: 3584032; HomoloGene: 47607; GeneCards: LIN28B; OMA:LIN28B - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)
Chromosome 6 (human)Genomic location for LIN28BGenomic location for LIN28B
Band6q16.3-q21Start104,936,616 bp
End105,083,332 bp
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)
Chromosome 10 (mouse)Genomic location for LIN28BGenomic location for LIN28B
Band10|10 B2Start45,252,716 bp
End45,362,491 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • placenta

  • buccal mucosa cell

  • gonad

  • testicle

  • secondary oocyte

  • sperm

  • decidua

  • Brodmann area 23

  • right testis

  • left testis
Top expressed in
  • tail of embryo

  • zygote

  • secondary oocyte

  • embryo

  • embryo

  • primary oocyte

  • genital tubercle

  • spermatocyte

  • epiblast

  • morula
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

389421

380669

Ensembl

ENSG00000187772

ENSMUSG00000063804

UniProt

Q6ZN17

Q45KJ6

RefSeq (mRNA)

NM_001004317

NM_001031772
NM_001033152

RefSeq (protein)

NP_001004317

NP_001026942

Location (UCSC)Chr 6: 104.94 – 105.08 MbChr 10: 45.25 – 45.36 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Lin-28 homolog B is a protein that in humans is encoded by the LIN28B gene.

Function

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000187772Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000063804Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Lin-28 homolog B". Retrieved 2016-03-06.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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