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CARMIL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LK2, 3LK3
Identifiers
Aliases	CARMIL1, CARMIL, CARMIL1a, LRRC16, dJ501N12.1, dJ501N12.5, LRRC16A, leucine rich repeat containing 16A, capping protein regulator and myosin 1 linker 1
External IDs	OMIM: 609593; MGI: 1915982; HomoloGene: 9757; GeneCards: CARMIL1; OMA:CARMIL1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.2 Start 25,279,078 bp End 25,620,530 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A3.1 Start 24,196,327 bp End 24,464,778 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte Achilles tendon mucosa of transverse colon left coronary artery right hemisphere of cerebellum thoracic aorta Descending thoracic aorta ascending aorta testicle Top expressed in zygote secondary oocyte molar saccule primary oocyte otic vesicle spermatid vestibular sensory epithelium otic placode medullary collecting duct More reference expression data BioGPS n/a
Gene ontology Molecular function protein-containing complex binding protein binding Cellular component filamentous actin cell projection membrane plasma membrane macropinosome cell leading edge extracellular exosome cytoskeleton nucleus lamellipodium cytoplasm cytosol nuclear speck Biological process barbed-end actin filament uncapping positive regulation of lamellipodium organization negative regulation of barbed-end actin filament capping positive regulation of actin filament polymerization ruffle organization actin filament organization positive regulation of cell migration actin filament network formation blood coagulation positive regulation of substrate adhesion-dependent cell spreading macropinocytosis urate metabolic process cell migration positive regulation of stress fiber assembly lamellipodium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55604 68732 Ensembl ENSG00000079691 ENSMUSG00000021338 UniProt Q5VZK9 Q6EDY6 RefSeq (mRNA) NM_001173977 NM_017640 NM_026825 NM_177807 NM_001311122 NM_001384122 RefSeq (protein) NP_001167448 NP_060110 NP_001298051 NP_081101 NP_001371051 Location (UCSC) Chr 6: 25.28 – 25.62 Mb Chr 13: 24.2 – 24.46 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CARMIL1 is a protein that in humans is encoded by the CARMIL1 gene. The gene is also known as LRRC16, LRRC16A, CARMIL, or CARMIL1a.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000079691 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000021338 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "capping protein regulator and myosin 1 linker 1". Retrieved 2020-11-09.

Further reading

• Yang C, Pring M, Wear MA, Huang M, Cooper JA, Svitkina TM, et al. (August 2005). "Mammalian CARMIL inhibits actin filament capping by capping protein". Developmental Cell. 9 (2): 209–221. doi:10.1016/j.devcel.2005.06.008. PMC 2628720. PMID 16054028.
• Liang Y, Niederstrasser H, Edwards M, Jackson CE, Cooper JA (December 2009). "Distinct roles for CARMIL isoforms in cell migration". Molecular Biology of the Cell. 20 (24): 5290–5305. doi:10.1091/mbc.E08-10-1071. PMC 2793302. PMID 19846667.
• Gunjaca G, Boban M, Pehlić M, Zemunik T, Budimir D, Kolcić I, et al. (February 2010). "Predictive value of 8 genetic loci for serum uric acid concentration". Croatian Medical Journal. 51 (1): 23–31. doi:10.3325/cmj.2010.51.23. PMC 2829178. PMID 20162742.

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