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La Chambre d'Echo was heavily inspired by Der Narrenturm, an old Austrian hospital and psychiatric ward that has since become a museum of diseases, mutations and abnormalities of the human body. As a result, the lyrical focus is that of hospitals and medical care in general. The album artwork, in part, features Cantodea transforming into a large worm-like creature, reminiscent of the artwork for Marilyn Manson's Antichrist Superstar.
The packaging for La Chambre d'Echo is elaborate and extensive. The standard edition comes inside a 128-page, A4-sized book containing photography by Joachim Luetke, as well as handwritten lyrics provided by Cantodea. The photoshoot for the album was taken inside and around Der Narrenturm. The boxed set edition came in a linen-bound box and also included bookmarks, postcards, a translation guide and a pamphlet advertising Der Narrenturm; the included book was enclosed and sealed in an envelope. Curiously, the cover of the vinyl edition featured an image taken for the previous album, Es reiten die Toten so schnell (or "The Vampyre Sucking at His Own Vein'"). The vinyl edition features its own abridged version of the book as well as a poster. A postcard was included with the album, offering fans the chance to pre-order Flowers in Formaldehyde.