La Serna may refer to:
- La Serna, Palencia, Castile and León, Spain
- La Serna de Iguña, Cantabria, Spain
- La Serna del Monte, Community of Madrid, Spain
- La Serna High School, Whittier, California
See also
- All pages with titles containing La Serna
- Serna (disambiguation)
- de la Serna, a surname
- Laserna, a surname
- Laserna, a neighborhood of Laguardia, Álava, Spain
- Šernas, a surname
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