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Lactivicin

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Chemical compound
Lactivicin
Names
IUPAC name 2-(4-Acetamido-3-oxo-1,2-oxazolidin-2-yl)-5-oxooxolane-2-carboxylic acid
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
PubChem CID
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C10H12N2O7/c1-5(13)11-6-4-18-12(8(6)15)10(9(16)17)3-2-7(14)19-10/h6H,2-4H2,1H3,(H,11,13)(H,16,17)Key: ZUEKKUYIXILDAF-UHFFFAOYSA-N
SMILES
  • CC(=O)NC1CON(C1=O)C2(CCC(=O)O2)C(=O)O
Properties
Chemical formula C10H12N2O7
Molar mass 272.213 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Lactivicin is a non-beta-lactam antibiotic that is active against a range of Gram-positive and Gram-negative bacteria. Lactivicin demonstrates a similar affinity for penicillin-binding proteins to beta-lactam antibiotics and is also susceptible to beta-lactamase enzymes.

References

  1. Nozaki Y, Katayama N, Harada S, Ono H, Okazaki H (1989). "Lactivicin, a naturally occurring non-beta-lactam antibiotic having beta-lactam-like action: biological activities and mode of action". J. Antibiot. 42 (10): 84–93. doi:10.7164/antibiotics.42.84. PMID 2493440.
  2. Harada S, Tsubotani S, Hida T, Ono H, Okazaki H (1986). "Structure of lactivicin, an antibiotic having a new nucleus and similar biological activities to β-lactam antibiotics". Tetrahedron Letters. 27 (51): 6229–6232. doi:10.1016/S0040-4039(00)85439-8.

External links

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