Lagasse or Lagassé is a surname. Notable people with the surname include:
- Bob Lagassé, Canadian politician
- Emeril Lagasse (born 1959), American celebrity chef
- Jan Lagasse, American curler
- Janet Lagasse, American tennis player
- Jeannette Boudreault-Lagassé (born 1941), Canadian writer
- Louis Lagassé (born 1947), Canadian businessman
- Roger Lagassé (born 1957), candidate in 1989 New Democratic Party leadership election (Canada)
- Scott Lagasse (born 1959), American racing driver
- Scott Lagasse Jr. (born 1981), American racing driver
- Tim Lagasse (born 1969), American puppeteer
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