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Laryngospasm
Specialty	ENT surgery

Laryngospasm is an uncontrolled or involuntary muscular contraction (spasm) of the vocal folds. It may be triggered when the vocal cords or the area of the trachea below the vocal folds detects the entry of water, mucus, blood, or other substance. It may be associated with stridor or retractions.

Signs and symptoms

Laryngospasm is characterized by involuntary spasms of the laryngeal muscles. It is associated with difficulty or inability to breathe or speak, retractions, a feeling of suffocation, which may be followed by hypoxia-induced loss of consciousness. It may be followed by paroxysmal coughing and in partial laryngospasms, a stridor may be heard. It requires prompt identification to avoid possibly fatal complications. It may present with loss of end-tidal carbon dioxide (for mechanically ventilated patients), chest or neck retractions and paradoxical chest wall movements.

The condition typically lasts less than 60 seconds, but in cases of partial blocking it may last 20 to 30 minutes and hinder inspiration, while exhalation remains easier.

Causes

Laryngospasm is a primitive protective airway reflex that functions to protect against aspiration. However, it may be detrimental if there is sustained closure of the glottis resulting in blockage of respiration that hinders the free flow of air. It may be triggered when the vocal cords or the area of the trachea below the vocal folds detects the entry of water, mucus, blood, or other substance.

It is most often reported 1) post-operatively after endotracheal extubation or 2) after sudden reflux of gastric contents. It is common in drowning. It is estimated that in 10% of cases of drowning as a response to inhalation of water, death occurs due to asphyxia due to laryngospasm without any water in the lungs. It is also a symptom of hypoparathyroidism. It can sometimes occur during sleep, waking up the affected person. These episodic interruptions of sleep have been attributed to acute irritation due to gastro-oesophageal reflux. Laryngospasm is also an unlikely but possible side effect of ketamine administration. Laryngospasm may happen in people with neurological disease.

In children, rapid detection and management are imperative to prevent deadly complications such as cardiac arrest, hypoxia and bradycardia.

Patients with a history of significant aspiration, asthma, exposure to airway irritants (smoke, dust, mold, fumes, use of Desflurane), upper respiratory infections, airway anomalies, light anesthesia and patients with acute mental status depression may be at increased risk.

Prevention

When gastroesophageal reflux disease (GERD) is the trigger, treatment of GERD can help manage laryngospasm. Proton pump inhibitors such as Dexlansoprazole (Dexilant), Esomeprazole (Nexium), and Lansoprazole (Prevacid) reduce the production of stomach acids, making reflux fluids less irritant. Prokinetic agents reduce the amount of acid available by stimulating movement in the digestive tract.

Patients who are prone to laryngospasm during illness can take measures to prevent irritation such as antacids to avoid acid reflux.

For acute context, making an upright position of the upper part of the body has been shown to shorten the spasm episodes. Fixation of the arms on stabilization of the body and slowing of breathing is also recommended.

Incidence

Incidence has been estimated at approximately 1% in both adult and pediatric populations. Its incidence is reported to be more than triple in the very young (birth to 3 months of age), increasing to 10% in those with reactive airways. Other sub-populations with high incidence of laryngospams include patients undergoing tonsillectomy and adenoidectomy (25%).

It is likely that more than 10% of drownings involve laryngospasm, but the evidence suggests that it is not usually effective at preventing water from entering the trachea.

Treatment

Most minor laryngospasm get better on its own for most people.

Laryngospasm is one of the most common intraoperative complications. It may be life-threatening as it involves reflex closure of the laryngeal muscles and thus results in inability to ventilate the patient. Treatment requires clearing secretions from the oropharynx, applying continuous positive airway pressure with 100% oxygen, followed by deepening the plane of anaesthesia with propofol, and/or paralyzing with succinylcholine.

See also

• Laryngotracheal stenosis

References

1. ^ Gavel G, Walker RW (26 August 2013). "Laryngospasm in anaesthesia". Continuing Education in Anaesthesia, Critical Care & Pain. 14 (2): 47–51. doi:10.1093/bjaceaccp/mkt031.
2. ^ Watson S (11 November 2022). Felson S (ed.). "Laryngospasm". Heartburn/GERD Guide. WebMD. Retrieved 8 February 2017.
3. ^ Gdynia HJ, Kassubek J, Sperfeld AD (2006). "Laryngospasm in neurological diseases". Neurocritical Care. 4 (2): 163–167. doi:10.1385/NCC:4:2:163. PMID 16627908. S2CID 37695632.
4. ^ Rogus-Pulia N, Barczi S, Robbins J (2017). "Disorders of swallowing.". In Halter JB, Ouslander JG, Studenski S, High KP, Asthana S, Supiano MA, Ritchie C (eds.). Hazzard's Geriatric Medicine and Gerontology (7th ed.). McGraw Hill. ISBN 978-0-07-183345-5.
5. Barrett KE, Barman SM, Brooks HL, Yuan JJ, eds. (2019). "Regulation of respiration". Ganong's Review of Medical Physiology (26th ed.). McGraw Hill. ISBN 978-1-260-12240-4.
6. Bilezikian JP, Khan A, Potts JT, Brandi ML, Clarke BL, Shoback D, et al. (October 2011). "Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research". Journal of Bone and Mineral Research. 26 (10): 2317–2337. doi:10.1002/jbmr.483. PMC 3405491. PMID 21812031.
7. Thurnheer R, Henz S, Knoblauch A (September 1997). "Sleep-related laryngospasm". The European Respiratory Journal. 10 (9): 2084–2086. doi:10.1183/09031936.97.10092084. PMID 9311507.
8. Melendez, Elliot; Bachur, Richard (May 2009). "Serious Adverse Events During Procedural Sedation With Ketamine". Pediatric Emergency Care. 25 (5): 325–328. doi:10.1097/PEC.0b013e3181a341e0. ISSN 0749-5161. PMID 19404223.
9. Gdynia, Hans-Jürgen; Kassubek, Jan; Sperfeld, Anne-Dorte (2006). "Laryngospasm in Neurological Diseases". Neurocritical Care. 4 (2): 163–167. doi:10.1385/NCC:4:2:163. ISSN 1541-6933. PMID 16627908.
10. Lobo PE, Hadaya I, Thoeny A (2020). "Anesthesia in head and neck surgery.". In Lalwani AK (ed.). Current Diagnosis & Treatment Otolaryngology—Head and Neck Surgery (4th ed.). McGraw Hill. ISBN 978-0-07-184764-3.
11. ^ Gavel G, Walker RW (April 2014). "Laryngospasm in anaesthesia". Continuing Education in Anaesthesia Critical Care & Pain. 14 (2): 47–51. doi:10.1093/bjaceaccp/mkt031.
12. North R (December 2002). "The pathophysiology of drowning". South Pacific Underwater Medicine Society Journal. Retrieved 4 October 2020.
13. Smith EB, Hunsberger J (2021). "Intraoperative complications and crisis management.". In Ellinas H, Matthes K, Alrayashi W, Bilge A (eds.). Clinical Pediatric Anesthesiology. McGraw Hill. ISBN 978-1-259-58574-6.

Further reading

• Larson CP (November 1998). "Laryngospasm--the best treatment". Anesthesiology. 89 (5): 1293–1294. doi:10.1097/00000542-199811000-00056. PMID 9822036.

External links

• Anesthesia
• Larynx disorders
• Otorhinolaryngology