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LEFTY1
Identifiers
Aliases	LEFTY1, LEFTB, LEFTYB, left-right determination factor 1
External IDs	OMIM: 603037; MGI: 107405; HomoloGene: 49231; GeneCards: LEFTY1; OMA:LEFTY1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q42.12 Start 225,886,282 bp End 225,911,382 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H4 Start 180,762,587 bp End 180,765,965 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon body of pancreas rectum testicle gonad endometrium appendix epithelium of colon monocyte cerebellar hemisphere Top expressed in neural plate lateral plate mesoderm primitive endoderm Region I of hippocampus proper endothelial cell of lymphatic vessel lip ankle joint embryo islet of Langerhans skin of external ear More reference expression data BioGPS n/a
Gene ontology Molecular function transforming growth factor beta receptor binding cytokine activity growth factor activity Cellular component extracellular region extracellular space Biological process regulation of apoptotic process multicellular organism development positive regulation of pathway-restricted SMAD protein phosphorylation heart morphogenesis determination of left/right symmetry negative regulation of transcription by RNA polymerase II transforming growth factor beta receptor signaling pathway regulation of MAPK cascade SMAD protein signal transduction cell development BMP signaling pathway regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10637 13590 Ensembl ENSG00000243709 ENSMUSG00000038793 UniProt O75610 Q64280 RefSeq (mRNA) NM_020997 NM_010094 RefSeq (protein) NP_066277 NP_034224 Location (UCSC) Chr 1: 225.89 – 225.91 Mb Chr 1: 180.76 – 180.77 Mb PubMed search
Wikidata
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Left-right determination factor 1 is a protein that in humans is encoded by the LEFTY1 gene.

Function

This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

See also

• Lefty
  • Lefty-1

References

1. ^ GRCh38: Ensembl release 89: ENSG00000243709 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000038793 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Left-right determination factor 1". Retrieved 2016-08-03.

Further reading

• Besser D (2004). "Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3". J. Biol. Chem. 279 (43): 45076–84. doi:10.1074/jbc.M404979200. PMID 15308665.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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