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Leonidas D. Marinelli

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American radiologist (1906–1974)
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Leonidas Donato Osvaldo Marinelli
Born(1906-11-28)28 November 1906
Buenos Aires, Argentina
Died13 September 1974(1974-09-13) (aged 67)
Hinsdale, Illinois
Alma materColumbia University, Cooper Union
Known forLong-term effects of radium in humans, whole-body counting, Marinelli beaker
Scientific career
FieldsCancer, radiation protection, human radiobiology, spectrometry
Institutions
Doctoral advisorI. Rabi
Other academic advisorsGioacchino Failla

Leonidas D. Marinelli (28 November 1906 – 13 September 1974) was the American radiological physicist who is best known for founding the field of Human Radiobiology and developing the Marinelli Beaker.

Early life and education

Marinelli was born of Italian parents in Buenos Aires, Argentina, on November 28, 1906, eldest son of 6 children of bank owner Vincenzo Marinelli and Amelia Sammartino Marinelli. He was 11 when his father died of a heart attack. He then returned with his widowed mother and her children to the family seat in Agnone, Italy, where the Marinelli family established their bell foundry in the 12th century. Leonidas graduated from the Volta Institute of Naples in October, 1925, with highest honors and a gold Queen Victoria coin. Two months after his nineteenth birthday, he emigrated to New York City and worked as a meter tester while studying at Cooper Union Night School of Electrical Engineering. In 1929, he was hired by Dr. Gioacchino Failla, former student of Marie Curie, to the biophysical laboratory at Memorial Cancer Hospital, New York City, known today as Memorial Sloan Kettering Cancer Center). A few months later, Leonidas measured the gamma ray intensities of radium, previously unquantified, in electrostatic units which were convertible to the x-ray roentgen unit. This made possible the comparison of xrays and gamma rays, later useful to evaluations of cancer therapies. By 1933, he coauthored his first publication with Failla, Edith Quimby, and John E. Rose. In 1935, he became Assistant Physicist. In 1938, he completed all course requirements for the PhD at Columbia University and had published 5 papers in radiological journals.

Career

Marinelli became an independent scientist in the 1940s. In 1941, he published papers that dealt with post-irradiation blood studies and early tracer work on cancer. In February, 1942, he published the theoretical basis for internal radiation dosimetry that provided the basis for nuclear medicine. In 1942, Marinelli established the principles for dosage determination of internal radioisotopes in the human body. In 1946, he developed the systematic dosimetry to distribute radioactive iodine to treat all locations of the metastases of a patient's thyroid cancer. This breakthrough was followed by autoradiography techniques and a Review of Modern Physics report on beta rays. The explosive growth of radiation medicine enlarged his responsibilities to the Head of Physics at Memorial-Sloan Kettering Institute.

In 1948, he added to his publication of internal radiation dosimetry the supplementary biological considerations contributed by Edith Quimby. In the same year, he moved to the Argonne National Laboratory, with a position on the University of Chicago faculty. Here, with John Rose, he provided early leadership and scientific direction of the Radiological Physics Division and the Biology and Medical Research Division. In 1950, he invented the Whole Body Counter that directly detected radioactive elements emitted from individuals who were previously contaminated in factories using radium, in nuclear industries, or by nuclear fallout. In 1953, he improved the "twin" scintillation low-level gamma-ray crystal spectrometry method to detect and locate elements that are naturally radioactive in the human body. These methods were quickly copied in laboratories throughout the world and yielded insights into the human metabolisms of many elements and their compounds. In 1956, he developed the twin scintillator method for dosimetry and spectrometry of fast neutrons, and its application to the measurement of cosmic-ray neutron background. Using this method, his investigations obtained the total content of natural potassium in the human body.

He authored review articles on dosimetry in the Annual Review of Nuclear Science, in Radiation Biology, and in the Dosimetry, Sonderdruck aus Handbuch der Medizinischen Radiologie. His studies of physics dealt with electron diffusion from point sources in air, and with the cosmic ray background. In radiology he pioneered the detection of minimal burdens of radioactivity in humans, studying their distribution and variation in tissues and the epidemiology of chronic low levels of radiation. The Center for Human Radiobiology, which now has the responsibility for all AEC-supported research on the effects of internally deposited radioisotopes, grew out of his effort.

Inventions and patents

In 1950, Marinelli pioneered the Whole Body Counter, a low-level gamma-ray detector, and applied it to study the long-term effects of radium in people injected with radium in the 1920s and 1930s. The WBC used thallium-activated sodium iodide crystals. In radiology, he detected radium distribution and variation in tissues, and the epidemiology of chronic low levels of radiation

US Patent 2,795,703A - Isadore B. Berlman and Leonidas D. Marinelli, "Apparatus for counting fast neutrons in the presence of gamma rays", issued 1957, applied for 1954. Under military supervision, this patent was assigned to the Atomic Energy Commission.

Marinelli devised and applied the “twin” scintillator method for the dosimetry and spectrometry of fast neutrons to the measurement of cosmic neutron background. His spectrometric method was copied in many laboratories throughout the world and has yielded insights into the human metabolisms of many elements and their compounds.

Marinelli beaker

In 1943, Marinelli devised a beaker to analyze the radioactive liquids in the systematic dosimetry of radioactive iodine for metastasized thyroid cancer. The original version of the Marinelli beaker, consisted of a pyrex/glass laboratory beaker with a central hollow tube projecting from the bottom. A detector, usually a glass GM tube designed for gamma counting, was positioned in the central tube while the beaker was filled with the sample. Since the sample effectively surrounded the detector, the counting efficiency was greater than would be the case if the sample were in any other type of container.

The following footnote regarding the Marinelli beaker is found in a report by R.F. Hill, G.J. Hine and L.D. Marinelli (1950) of the Sloan-Kettering Institute in New York: "This equipment first designed by one of the present authors (L.D.M.) and in use in this laboratory since 1943, can now be obtained from Technical Associates, Inc. Glendale, California."

Awards and honors

Research

References

  1. Rossi, Harald H., letter to Mrs. Marinelli (April 25, 1975)
  2. John Rundo, HEALTH PHYSICS, Volume 35, July, 1978, Pp 5-6
  3. L.D. Marinelli, Dosage determination with radioactive isotopes-I: Fundamental dosage formulae. American Journal of Roentgenology and Radium Therapy 47/2 (Feb. 1942):210-216
  4. Fano, U., Leonidas D. Marinelli (1906–1974). Radiation Research (March 1975)61/3:538-539
  5. Argonne National Laboratory Report-4488, Report 4571
  6. L. D. Marinelli British Journal of Radiology Suppl.(Nov 1956)7:38-43
  7. L. D. Marinelli, British Journal of Radiology Suppl.(Nov 1956)7:38-43
  8. Rossi, Harald H., Letter, April 15, 1975
  9. (Patent # 2-795-703, June 11, 1957)
  10. Berlman, I.B. and L.D. Marinelli. June 25, 1956. Twin scintillation fast neutron detector. Review of Scientific Instruments, 27/110:858-859
  11. L.D. Marinelli (Supplement by H.A. May),1961. Use of low-level gamma-ray scintillation spectrometry in the measurements of activity in human beings. Radioactivity in Man. Ed. H. Meneely, C. C. Thomas, Springfield, IL:16-30.
  12. Miller, C.E., and L.D. Marinelli.The gamma-ray activity of contemporary man. Science, 124 (3212) (July 20, 1956):122-123
  13. RADIATION RESEARCH, Vol 61, No 3, Mar., 1975, Pp 538-539. "Obituary: Leonidas D. Marinelli 1906 - 1974, by Ugo Fano www.jstor.org/stable/3574129
  14. HEALTH PHYSICS, Volume 35 (July 1978): 5-6. " In Memoriam. Leonidas D. Marinelli, 28 November 1906 - 13 September 1974 " by John Rundo, Argonne National laboratory and the University of Chicago. This issue and the proceedings of the Society are dedicated to Leonidas D. Marinelli. Pergamon Press Ltd, 1978, printed in Great Britain © Health Physics Society
  15. Marinelli, L.D. 1956.The use of Na-T1 crystal spectrometers in the study of gamma-ray activity in vivo: A summary of developments at the Argonne national laboratory. Brit. Journ. of Radiol. Supplement 7 (Nov.): 38-43. (London Brit. Inst. Of Radiology)
  16. May, H.A. and L.D. Marinelli. 1962. Sodium Iodide Systems: Optimum crystal dimensions and origin of background.Proceedings of the Symposium on Whole Body Counting, IAEA, Vienna (June 12–16): 15-36.
  17. RADIATION RESEARCH, Vol 61, No 3, Mar., 1975, Pp 538-539. "Obituary: Leonidas D. Marinelli 1906 - 1974 by Ugo Fano www.jstor.org/stable/3574129
  18. Berlman, Isadore B., Marinelli, Leonidas D. (16 March 1954). Apparatus for counting fast neutrons in the presence of gamma rays. Vol. Patent #2, 795, 703A. Washington, D.C.: U.S. Patent and Trademark Office.{{cite book}}: CS1 maint: multiple names: authors list (link)
  19. Rossi, Harald. H., April 25, 1975. Essay: Leonidas D. Marinelli.
  20. A Comparison of Iodine-131 Counting Methods|journal=Nucleonics|date=October 1952|page=57
  21. Bruner, H.D.; Perkinson, J.D. (October 1952). "A Comparison of Iodine-131 Counting Methods". Nucleonics: 57.
  22. Hill, R.F., Hine, G.J. and Marinelli, L.D. (February 1950). "The Quantitative Determination of Gamma Radiation in Biological Research". American Journal of Roentgenology and Radium Therapy. 63 (2): 160–169. PMID 15402761.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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