Lethe (Λήθη) is the river of forgetfulness in Greek mythology'.
Lethe may also refer to:
- Lethe (daughter of Eris), in Greek mythology, the personification of forgetfulness and oblivion
- River Lethe, a river in Alaska
- Lethe (genus), a butterfly genus in the family Nymphalidae
- Lethe (Hunte), a river of lower Saxony, Germany, tributary of the Hunte
- Lethe (video game), an adventure/survival horror video game released in 2016
- Lethe Press, an American publishing company
- Sailor Lethe, a minor character in the Sailor Moon metaseries
- A song from the 1995 album The Gallery by the melodic death metal band Dark Tranquillity
- A song from the 2012 album Gamma Knife by the avant-garde metal band Kayo Dot
- "Lethe" (Person of Interest), an episode of the TV series Person of Interest
- "Lethe" (Star Trek: Discovery), an episode of the science fiction television series
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