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Leukotriene-C4 hydrolase (EC 3.4.19.14, gamma-glutamyl leukotrienase) is an enzyme. Gamma-glutamyltransferase 5 (GGT5) is a human gene which encodes an enzyme protein that belongs to this class of enzymes. This enzyme catalyses the following chemical reaction

leukotriene C4 + H₂O ${\displaystyle \rightleftharpoons }$ leukotriene D4 + L-glutamate

The mouse enzyme is specific for leukotriene C4.

References

1. Carter BZ, Wiseman AL, Orkiszewski R, Ballard KD, Ou CN, Lieberman MW (May 1997). "Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice". The Journal of Biological Chemistry. 272 (19): 12305–10. doi:10.1074/jbc.272.19.12305. PMID 9139674.
2. Shi ZZ, Han B, Habib GM, Matzuk MM, Lieberman MW (August 2001). "Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response". Molecular and Cellular Biology. 21 (16): 5389–95. doi:10.1128/mcb.21.16.5389-5395.2001. PMC 87261. PMID 11463821.
3. Han B, Luo G, Shi ZZ, Barrios R, Atwood D, Liu W, Habib GM, Sifers RN, Corry DB, Lieberman MW (August 2002). "Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo". The American Journal of Pathology. 161 (2): 481–90. doi:10.1016/s0002-9440(10)64204-6. PMC 1850737. PMID 12163373.
4. Wickham S, West MB, Cook PF, Hanigan MH (July 2011). "Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes". Analytical Biochemistry. 414 (2): 208–14. doi:10.1016/j.ab.2011.03.026. PMC 3099546. PMID 21447318.

External links

• Leukotriene-C4+hydrolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 3.4.19