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Lev T. Perelman

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Physician and scientist

Lev T. Perelman
Scientific career
FieldsBiological physics, Bioengineering
InstitutionsHarvard University

Harvard Medical School

Beth Israel Deaconess Medical Center
Website

Lev T. Perelman is an American biological physicist and bioengineer at Harvard. He holds the Mary Tolan and Edward Grzelakowski Endowed Chair, is a professor of medicine at Harvard Medical School, and is the Director of the Center for Advanced Biomedical Imaging and Photonics at Beth Israel Deaconess Medical Center. He is known for his work on biomedical light scattering spectroscopy and application of optics and spectroscopy to life sciences and developmental and cell biology.

Background and education

Perelman is the son of theoretical physicist Theodore L. Perelman, who solved the Conjugate convective heat transfer problem and made contributions in the development of a two-temperature model that describes electron and phonon temperature distributions in metals heated by ultrashort-pulsed lasers.

Perelman completed his undergraduate degree in theoretical physics from Belarus University and doctoral degree in physics from Institute of Physics in Minsk in 1989. He joined MIT in 1992 as a postdoctoral fellow in biological physics.

Career

Perelman was appointed a principal scientist at MIT in 1995. He joined Harvard faculty in 2000 where he is currently a professor.

Perelman was a member of the United States Department of Health and Human Services Joint Working Group charged with setting up funding priorities in oncologic imaging in the U.S.

Research

Perelman with Vadim Backman, an HST graduate student, introduced biomedical light scattering spectroscopy (LSS) in 1998. This approach was later applied for detection of precancer in esophagus, colon, urinary bladder and oral cavity, cervix, pancreatic cysts, and bile duct. This technique was later extended to subcellular scales with development of confocal light absorption and scattering spectroscopic microscopy for label-free subcellular functional imaging, sensing chromatin packing in live cells, and demonstrating that exosomes promote tumorigenesis.

Perelman's other contributions include demonstration of the world's first single-molecule detection with Surface-enhanced Raman Spectroscopy (SERS), and explanation of the critical role of stress confinement in short pulse laser ablation and laser surgery. He also developed with John Marshall the first non-hydrostatic model of the ocean known as the MIT General Circulation Model.

References

  1. ^ "Lev Perelman Harvard Profile". Harvard University. Archived from the original on December 7, 2022.
  2. "Light-scattering tool peers into pancreas to find cancer". NSF - National Science Foundation. Retrieved April 3, 2023.
  3. New tool for early detection of pancreatic cancer!, retrieved April 3, 2023
  4. WINTERS, CATHERINE (June 16, 2017). "The Latest Cancer Research News to Cheer About". Parade. Retrieved April 2, 2023.
  5. Anisimov, SI; Kapeliovich, BL; Perelman, TL (February 1974). "Electron emission from metal surfaces exposed to ultrashort laser pulses" (PDF). Soviet Physics JETP. 39 (2).
  6. Ilev, Ilko K.; Boppart, Stephen A.; Andersson-Engels, Stefan; Kim, Beop-Min; Perelman, Lev; Tuchin, Valery (March 2014). "Introduction to the issue on biophotonics". IEEE Journal of Selected Topics in Quantum Electronics. 20 (2): 4–7. Bibcode:2014IJSTQ..20....4I. doi:10.1109/JSTQE.2014.2313622. ISSN 1558-4542.
  7. Qiu, Le; Zhang, Lei; Turzhitsky, Vladimir; Khan, Umar; Zakharov, Yuri; Kantekure, Kanchan; Vitkin, Edward; Itzkan, Irving; Pleskow, Douglas K.; Sawhney, Mandeep; Berzin, Tyler M.; Goldsmith, Jeffrey D.; Perelman, Lev T. (2019). "Multispectral Endoscopy with Light Gating for Early Cancer Detection". IEEE Journal of Selected Topics in Quantum Electronics. 25 (1): 7201309. Bibcode:2019IJSTQ..2554608Q. doi:10.1109/JSTQE.2018.2854608. ISSN 1077-260X. PMC 6594557. PMID 31244520.
  8. Perelman, L. T.; Backman, V.; Wallace, M.; Zonios, G.; Manoharan, R.; Nusrat, A.; Shields, S.; Seiler, M.; Lima, C.; Hamano, T.; Itzkan, I.; Van Dam, J.; Crawford, J. M.; Feld, M. S. (January 19, 1998). "Observation of Periodic Fine Structure in Reflectance from Biological Tissue: A New Technique for Measuring Nuclear Size Distribution". Physical Review Letters. 80 (3): 627–630. Bibcode:1998PhRvL..80..627P. doi:10.1103/PhysRevLett.80.627.
  9. Wallace, Michael B.; Perelman, Lev T.; Backman, Vadim; Crawford, James M.; Fitzmaurice, Marianne; Seiler, Maurice; Badizadegan, Kamran; Shields, Steven J.; Itzkan, Irving; Dasari, Ramachandra R.; Van Dam, Jacques; Feld, Michael S. (September 1, 2000). "Endoscopic detection of dysplasia in patients with Barrett's esophagus using light-scattering spectroscopy". Gastroenterology. 119 (3): 677–682. doi:10.1053/gast.2000.16511. ISSN 0016-5085. PMID 10982761.
  10. Qiu, Le; Pleskow, Douglas K.; Chuttani, Ram; Vitkin, Edward; Leyden, Jan; Ozden, Nuri; Itani, Sara; Guo, Lianyu; Sacks, Alana; Goldsmith, Jeffrey D.; Modell, Mark D.; Hanlon, Eugene B.; Itzkan, Irving; Perelman, Lev T. (May 2010). "Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett's esophagus". Nature Medicine. 16 (5): 603–606. doi:10.1038/nm.2138. ISSN 1546-170X. PMC 3052700. PMID 20383155.
  11. ^ Backman, V.; Wallace, M. B.; Perelman, L. T.; Arendt, J. T.; Gurjar, R.; Müller, M. G.; Zhang, Q.; Zonios, G.; Kline, E.; McGillican, T.; Shapshay, S.; Valdez, T.; Badizadegan, K.; Crawford, J. M.; Fitzmaurice, M. (July 2000). "Detection of preinvasive cancer cells". Nature. 406 (6791): 35–36. doi:10.1038/35017638. ISSN 1476-4687. PMID 10894529. S2CID 4383575.
  12. Gurjar, Rajan S.; Backman, Vadim; Perelman, Lev T.; Georgakoudi, Irene; Badizadegan, Kamran; Itzkan, Irving; Dasari, Ramachandra R.; Feld, Michael S. (November 2001). "Imaging human epithelial properties with polarized light-scattering spectroscopy". Nature Medicine. 7 (11): 1245–1248. doi:10.1038/nm1101-1245. ISSN 1546-170X. PMID 11689891. S2CID 10756302.
  13. Georgakoudi, Irene; Sheets, Ellen E.; Müller, Markus G.; Backman, Vadim; Crum, Christopher P.; Badizadegan, Kamran; Dasari, Ramachandra R.; Feld, Michael S. (March 1, 2002). "Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo". American Journal of Obstetrics and Gynecology. 186 (3): 374–382. doi:10.1067/mob.2002.121075. ISSN 0002-9378. PMID 11904594.
  14. Sokolov, Konstantin; Drezek, Rebekah; Gossage, Kirk; Richards-Kortum, Rebecca (1999). "Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morphology". Optics Express. 5 (13). Optica Publishing Group: 302–317. Bibcode:1999OExpr...5..302S. doi:10.1364/oe.5.000302. PMID 19401735. Retrieved April 3, 2023.
  15. Zhang, Lei; Pleskow, Douglas K.; Turzhitsky, Vladimir; Yee, Eric U.; Berzin, Tyler M.; Sawhney, Mandeep; Shinagare, Shweta; Vitkin, Edward; Zakharov, Yuri; Khan, Umar; Wang, Fen; Goldsmith, Jeffrey D.; Goldberg, Saveli; Chuttani, Ram; Itzkan, Irving (March 13, 2017). "Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy". Nature Biomedical Engineering. 1 (4): 1–7. doi:10.1038/s41551-017-0040. ISSN 2157-846X. PMC 5646377. PMID 29057146.
  16. Pogue, Brian W.; Wang, Kenneth K. (April 12, 2017). "Cancer diagnostics: Light scattering by pancreatic cysts". Nature Biomedical Engineering. 1 (4): 1–2. doi:10.1038/s41551-017-0060. ISSN 2157-846X. S2CID 90919028.
  17. Pleskow, Douglas K.; Sawhney, Mandeep S.; Upputuri, Paul K.; Berzin, Tyler M.; Coughlan, Mark F.; Khan, Umar; Glyavina, Maria; Zhang, Xuejun; Chen, Liming; Sheil, Conor J.; Cohen, Jonah M.; Vitkin, Edward; Zakharov, Yuri N.; Itzkan, Irving; Zhang, Lei (January 7, 2023). "In vivo detection of bile duct pre-cancer with endoscopic light scattering spectroscopy". Nature Communications. 14 (1): 109. Bibcode:2023NatCo..14..109P. doi:10.1038/s41467-022-35780-7. ISSN 2041-1723. PMC 9825389. PMID 36611024.
  18. Itzkan, Irving; Qiu, Le; Fang, Hui; Zaman, Munir M.; Vitkin, Edward; Ghiran, Ionita C.; Salahuddin, Saira; Modell, Mark; Andersson, Charlotte; Kimerer, Lauren M.; Cipolloni, Patsy B.; Lim, Kee-Hak; Freedman, Steven D.; Bigio, Irving; Sachs, Benjamin P. (October 30, 2007). "Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels". Proceedings of the National Academy of Sciences. 104 (44): 17255–17260. Bibcode:2007PNAS..10417255I. doi:10.1073/pnas.0708669104. ISSN 0027-8424. PMC 2077242. PMID 17956980.
  19. Cassiday, Laura (January 1, 2008). "Bio Sphere: A first CLASS microscope". Analytical Chemistry. 80 (1): 29. doi:10.1021/ac085998b. ISSN 0003-2700.
  20. Pettinato, Giuseppe; Coughlan, Mark F.; Zhang, Xuejun; Chen, Liming; Khan, Umar; Glyavina, Maria; Sheil, Conor J.; Upputuri, Paul K.; Zakharov, Yuri N.; Vitkin, Edward; D’Assoro, Antonino B.; Fisher, Robert A.; Itzkan, Irving; Zhang, Lei; Qiu, Le (August 20, 2021). "Spectroscopic label-free microscopy of changes in live cell chromatin and biochemical composition in transplantable organoids". Science Advances. 7 (34): eabj2800. Bibcode:2021SciA....7.2800P. doi:10.1126/sciadv.abj2800. ISSN 2375-2548. PMC 8373132. PMID 34407934.
  21. Melo, Sonia A.; Sugimoto, Hikaru; O’Connell, Joyce T.; Kato, Noritoshi; Villanueva, Alberto; Vidal, August; Qiu, Le; Vitkin, Edward; Perelman, Lev T.; Melo, Carlos A.; Lucci, Anthony; Ivan, Cristina; Calin, George A.; Kalluri, Raghu (November 10, 2014). "Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis". Cancer Cell. 26 (5): 707–721. doi:10.1016/j.ccell.2014.09.005. ISSN 1535-6108. PMC 4254633. PMID 25446899.
  22. Kneipp, Katrin; Wang, Yang; Kneipp, Harald; Perelman, Lev T.; Itzkan, Irving; Dasari, Ramachandra R.; Feld, Michael S. (March 3, 1997). "Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)". Physical Review Letters. 78 (9): 1667–1670. Bibcode:1997PhRvL..78.1667K. doi:10.1103/PhysRevLett.78.1667.
  23. Itzkan, I; Albagli, D; Dark, M L; Perelman, L T; von Rosenberg, C; Feld, M S (March 14, 1995). "The thermoelastic basis of short pulsed laser ablation of biological tissue". Proceedings of the National Academy of Sciences. 92 (6): 1960–1964. Bibcode:1995PNAS...92.1960I. doi:10.1073/pnas.92.6.1960. ISSN 0027-8424. PMC 42402. PMID 7892208.
  24. Marshall, John; Adcroft, Alistair; Hill, Chris; Perelman, Lev; Heisey, Curt (March 15, 1997). "A finite-volume, incompressible Navier Stokes model for studies of the ocean on parallel computers". Journal of Geophysical Research: Oceans. 102 (C3): 5753–5766. Bibcode:1997JGR...102.5753M. doi:10.1029/96JC02775.
  25. Marshall, John; Hill, Chris; Perelman, Lev; Adcroft, Alistair (March 15, 1997). "Hydrostatic, quasi-hydrostatic, and nonhydrostatic ocean modeling". Journal of Geophysical Research: Oceans. 102 (C3): 5733–5752. Bibcode:1997JGR...102.5733M. doi:10.1029/96JC02776.
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