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Life Itself may refer to:

Films

• Life Itself (2014 film), a documentary, film adaptation of film critic Roger Ebert's memoir
• Life Itself (2018 film), an English-language romance drama film

Songs

• "Life Itself" (George Harrison song), a song by George Harrison from Somewhere in England
• "Life Itself", a song by Glass Animals from How to Be a Human Being
• "Life Itself", a song by Bruce Springsteen from Working on a Dream

Books

• Life Itself: A Memoir, a 2011 memoir by film critic Roger Ebert
• Life Itself: Its Origin and Nature, a 1981 book by Francis Crick
• Life Itself: A Comprehensive Inquiry Into the Nature, Origin, and Fabrication of Life, a 1991 book by Robert Rosen

Other

• Life Itself with Sanjay Gupta and Marc Hodosh, a health conference
• "Life, Itself", a Star Trek: Discovery season 5 episode

• Disambiguation pages