Linolenate 9R-lipoxygenase

Linolenate 9R-lipoxygenase (EC 1.13.11.61, NspLOX, (9R)-LOX, linoleate 9R-dioxygenase) is an enzyme with systematic name alpha-linolenate:oxygen (9R)-oxidoreductase. This enzyme catalyses the following chemical reaction

alpha-linolenate + O₂

\rightleftharpoons

(9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate

In cyanobacteria the enzyme is involved in oxylipin biosynthesis.

References

Jernerén F, Hoffmann I, Oliw EH (March 2010). "Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus". Archives of Biochemistry and Biophysics. 495 (1): 67–73. doi:10.1016/j.abb.2009.12.022. PMID 20043865.
Andreou AZ, Vanko M, Bezakova L, Feussner I (June 2008). "Properties of a mini 9R-lipoxygenase from Nostoc sp. PCC 7120 and its mutant forms". Phytochemistry. 69 (9): 1832–7. doi:10.1016/j.phytochem.2008.03.002. PMID 18439634.
Lang I, Göbel C, Porzel A, Heilmann I, Feussner I (March 2008). "A lipoxygenase with linoleate diol synthase activity from Nostoc sp. PCC 7120" (PDF). The Biochemical Journal. 410 (2): 347–57. doi:10.1042/BJ20071277. PMID 18031288.

v t e Oxidoreductases: monooxygenases (EC 1.13)
1.13.11: two atoms of oxygen	lipoxygenase: Arachidonate 5-lipoxygenase Arachidonate 12-lipoxygenase/ALOX12 Arachidonate 8-lipoxygenase Arachidonate 15-lipoxygenase/ALOX15 Linoleate 11-lipoxygenase other dioxygenase: Catechol dioxygenase Homogentisate 1,2-dioxygenase Cysteine dioxygenase 4-Hydroxyphenylpyruvate dioxygenase Indoleamine 2,3-dioxygenase Chlorite dismutase
1.13.12: one atom of oxygen	Firefly luciferase
1.13.99: other	Inositol oxygenase

1.13.11: two atoms of oxygen

1.13.12: one atom of oxygen

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)