The following is a list of Sites of Special Scientific Interest in the Berwickshire and Roxburgh Area of Search. For other areas, see List of SSSIs by Area of Search.
- Abbey St Bathans Woodlands
- Adderstonlee Moss
- Alemoor West Loch and Meadow
- Allan Water Hillhead
- Ashkirk Loch
- Berwickshire Coast (Intertidal)
- Branxholme Easter Loch
- Branxholme Wester Loch
- Buckstruther Moss
- Burnmouth Coast
- Catshawhill
- Coldingham Common, Long Moss
- Coldingham Loch
- Cragbank and Wolfehopelee Woods
- Crook Burn Dyeshaugh
- Din Moss and Hoselaw Loch
- Drone Moss
- Foulden Burn
- Gordon Moss
- Greenlaw Moor
- Hareheugh Craigs
- Hummelknowes Moss
- Jedwater Woodlands
- Kershope Bridge
- Kielderhead Moors : Carter Fell to Peel Fell
- Kingside Loch
- Kippilaw Moss
- Kirkton Burn Meadow
- Lammer Law
- Langholm - Newcastleton Hills
- Langton Lees Cleugh
- Lennel, Charley's Brae
- Lintmill Railway Cutting
- Long Moss - Drinkstone Hill
- Longnewton Cutting
- Lurgie Loch
- Lynnwood - Whitlaw Wood, Slitrig
- Makerstoun - Corbie Craigs to Trows' Craigs
- Minto Craigs
- Old Cambus Quarry
- Oxendean Burn
- Palmers Hill Railway Cutting
- Pease Bay Coast
- Pease Bridge Glen
- Redden Bank Lime Works
- River Tweed
- Siccar Point
- Slaidhills Moss
- St Abbs Head to Fast Castle Head
- The Hirsel
- Whiteadder Water
- Whitlaw Bank to Hardies Hill
- Woodhead Moss
- Yetholm Loch