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List of banned substances in Major League Baseball

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Major League Baseball's drug policy prohibits players from using, possessing, selling, facilitating the sale of, distributing, or facilitating the distribution of any Drug of Abuse and/or Steroid. Any and all drugs or substances listed under Schedule II of the Controlled Substances Act are considered drugs of abuse covered by the Program. Players who require prescription medication can still use it with a "Therapeutic Use Exemption" granted by MLB.

In December 2019, MLB removed cannabinoids and added cocaine and opiates to its list of Drugs of Abuse. However, players were told that they could still be suspended for possessing or selling cannabis, or driving under the influence of cannabis.

List of banned substances (not exhaustive)

Drugs of abuse

  1. Synthetic cannabinoids
  2. Cocaine
  3. LSD
  4. Opiates (e.g., fentanyl, oxycodone, heroin, codeine, and morphine)
  5. Amphetamines (e.g., MDMA (Ecstasy), MDA, Meth)
  6. "Bath salts" (e.g., cathinone, synthetic cathinone, MDPV)
  7. GHB
  8. Phencyclidine (PCP)

Performance enhancing substances (steroids, growth factors, hormone modulators, masking agents)

  1. Androstanediol
  2. Androstanedione
  3. Androstatrienedione (ATD)
  4. Androstanolone
  5. Androstenediol
  6. Androstenedione
  7. Androst-2-en-17-one (2-androstenone, delta-2)
  8. Androsterone
  9. Bolandiol
  10. Bolasterone
  11. Boldenone
  12. Boldione
  13. Calusterone
  14. Clenbuterol
  15. Clostebol (chlortestosterone)
  16. Danazol
  17. Dehydrochloromethyltestosterone (DHCMT, turinabol)
  18. Dehydroepiandrosterone (DHEA)
  19. Desoxy-methyltestosterone (DMT, madol)
  20. Dihydrotestosterone
  21. Drostanolone
  22. Epiandrosterone
  23. Epi-dihydrotestosterone
  24. Epitestosterone
  25. Ethylestrenol
  26. Fluoxymesterone
  27. Formebolone
  28. Furazabol
  29. Gestrinone
  30. Halodrol
  31. 4-Hydroxytestosterone
  32. 7-Keto-DHEA
  33. Mestanolone
  34. Mesterolone
  35. Methandienone
  36. Methandriol
  37. Methasterone (superdrol)
  38. Methenolone
  39. Methylclostebol
  40. Methyldienolone
  41. Methylnortestosterone
  42. Methylstenbolone (ultradrol, m-sten)
  43. Methyltestosterone
  44. Methyltrienolone (metribolone)
  45. Mibolerone
  46. Nandrolone
  47. Norbolethone
  48. Norandrostenediol
  49. Norandrostenedione
  50. Norandrosterone
  51. Norbolethone (genabol)
  52. Norclostebol
  53. Norethandrolone
  54. Noretiocholanolone
  55. Oxabolone
  56. Oxandrolone
  57. Oxymesterone
  58. Oxymetholone
  59. Prasterone (DHEA)
  60. Promagnon
  61. Prostanozol
  62. Quinbolone
  63. Selective androgen receptor modulators (SARMs)
  64. Stanozolol
  65. Stenbolone
  66. Testosterone
  67. Tetrahydrogestrinone
  68. Tibolone
  69. Trenbolone
  70. Zeranol
  71. Zilpaterol
  72. Any salt, ester, or ether of a drug or substance listed above
  73. Human growth hormone (hGH), including all fragments (e.g., AOD9604, hGH fragment 176-191) and releasing factors including GHRHs (e.g., CJC-1295, sermorelin, tesamorelin), GHSs (e.g., ghrelin and its mimetics (e.g., anamorelin, ibutamoren (MK-0677), ipamorelin), and peptides (e.g., alexamorelin, GHRP-2 (pralmorelin), GHRP-6, hexarelin)
  74. Insulin-like growth factor (IGF-1), including all isomers of IGF-1 (mechano growth factors, thymosin beta-4)
  75. Gonadotrophins (hCG), including LH and hCG
  76. Corticotrophins, including releasing factors (corticorelin)
  77. Erythropoiesis stimulating agents, including (erythropoietin (EPO), darbepoetin (dEPO), hematide, methoxy polyethylene glycol-epoetin beta (CERA))
  78. Aromatase inhibitors, including anastrozole, androstatrienedione (ATD), androstenetrione (6-OXO), aminoglutethimide, arimistane, exemestane, formestane, letrozole, and testolactone
  79. Selective estrogen receptor modulators (SERMs), including bazedoxifene, ospemifene, raloxifen, tamoxifen, and toremifen
  80. Other Anti-estrogens, including clomiphene, cyclofenil, and fulvestrant
  81. Myostatin modifying agents, including myostatin inhibitors (e.g., follistatin)
  82. Metabolic modifying agents, including Peroxisome Proliferator Activated Receptor δ (PPARδ) agonists (GW1516, GW501516, GW0742), AMP-activated protein kinase (AMPK) activators (AICAR, SR9009 (stenabolic)), meldonium (mildronate), trimetazidine
  83. HIF stabilizers, including roxadustat (FG-4592), molidustat (BAY 85-3934), FG-2216, BAY 87-2243.
  84. Masking agents, including diuretics, desmopressin, probenecid, plasma expanders (e.g., intravenous administration of albumin, dextran, hydroxyethyl starch and mannitol)
  85. Diuretics include acetazolamide, amiloride, bumetanide, canrenone, chlorthalidone, etacrynic acid, furosemide, indapamide, metolazone, spironolactone, thiazides (e.g., bendroflumethiazide, chlorothiazide, hydrochlorothiazide), triamterene, vaptans
  86. Gene doping, the use of nucleic acids that may alter genome sequences and/or gene expression, including gene editing, gene silencing, gene transfer, genetically modified cells

Stimulants

  1. Adrafinil
  2. Amfepramone (diethylproprion)
  3. Amiphenazole
  4. Amphetamine
  5. Amphetaminil
  6. Armodafinil
  7. Benfluorex
  8. Benzphetamine
  9. Benzylpiperazine
  10. Bromantan
  11. Carphedon
  12. Cathine (norpseudoephedrine)
  13. Chloroamphetamine
  14. Clobenzorex
  15. Cropropamide
  16. Crotetamide
  1. Dimethylamylamine
  2. Dimethylamphetamine
  3. 1,3-Dimethylbutylamine (DMBA)
  4. Ephedrine
  5. Etamivan
  6. Ethylamphetamine
  7. Etilefrine
  8. Famprofazone
  9. Fenbutrazate
  10. Fencamfamine
  11. Fenethylline
  12. Fenfluramine
  13. Fenproporex
  14. Furfenorex
  15. Heptaminol
  16. Isometheptene
  17. Levmetamphetamine
  18. Lisdexamphetamine
  19. Meclofenoxate
  20. Mefenorex
  21. Mephentermine
  22. Mesocarb
  23. Methylephedrine
  24. Methylhexaneamine (dimethylamylamine, DMAA)
  25. Methylphenidate
  26. Modafinil
  27. N,alpha-Diethylphenylethylamine (N,a-DEPEA)
  28. N-ethyl-1-phenyl-2-butanamine
  29. Nikethamide
  30. Norfenefrine
  31. Norfenfluramine
  32. Octodrine (DMHA)
  33. Octopamine
  34. Oxilofrine
  35. Parahydroxyamphetamine
  36. Pemoline
  37. Pentetrazol
  38. Phendimetrazine
  39. Phenethylamine
  40. Phenmetrazine
  41. Phenpromethamine
  42. Phentermine
  43. Prenylamine
  44. Prolintane
  45. Propylhexedrine
  46. Pyrovalerone
  47. Selegiline
  48. Sibutramine
  49. Strychnine
  50. Tuaminoheptane

Prohibited Substances may be added to the list only by the unanimous vote of HPAC, provided that the addition by the federal government of a substance to Schedule I, II, or III will automatically result in that substance being added to the list.

References

  1. "Are too many players getting therapeutic use exemptions?". ESPN.com. December 2, 2015.
  2. "Major League Baseball Drops Marijuana, Adds Opioids, Cocaine To 'Drugs Of Abuse' List". NPR. 2019-12-12. Retrieved 2022-07-18.
  3. "MLB: Players still subject to penalty for using pot". ESPN.com. February 29, 2020.
  4. MLB.com (July 1, 2015). "Prohibited Substance List" (PDF).
  5. "MAJOR LEAGUE BASEBALL'S MINOR LEAGUE DRUG PREVENTION AND TREATMENT PROGRAM" (PDF). Retrieved February 27, 2024.
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