The following is a list of professional baseball teams based in Fort Wayne, Indiana. The list includes the league(s) the Fort Wayne teams were members of, and the number championships won.
Professional (Major League Baseball)
| Team | Years | League | Class level | Affiliate | League titles | Notes |
|---|---|---|---|---|---|---|
| Fort Wayne Kekiongas | 1871 | National Association | Major League baseball | NA | 0 | League folded after one season. |
Professional (Minor League Baseball)
| Team | League | Class | Affiliate | First Season | Last Season | History |
|---|---|---|---|---|---|---|
| Fort Wayne Hoosiers | Northwestern League | Independent | None | 1883 | 1884 | League was unclassified |
| Fort Wayne | Indiana State League | Independent | None | 1888 | 1890 | League was unclassified |
| Fort Wayne | Northwestern League | Independent | None | 1891 | 1891 | League was unclassified |
| Fort Wayne | Western League | Class A | None | 1892 | 1892 | St. Paul Saints relocated to Fort Wayne |
| Fort Wayne | Western Interstate League | Class B | None | 1895 | 1895 | No nickname known. |
| Fort Wayne Farmers | Interstate League | Class C | None | 1896 | 1896 | Charter member of Interstate League |
| Fort Wayne Indians | Interstate League | Class B | None | 1897 | 1900 | 1900 League champions |
| Fort Wayne Railroaders | Western Association | Class A | None | 1901 | 1901 | League folded after 1901 season |
| Fort Wayne Railroaders | Central League | Class B | None | 1903 | 1905 | 1903 and 1905 league champions |
| Fort Wayne Railroaders | Interstate Association | Class C | None | 1906 | 1906 | League folded during season, League champions |
| Fort Wayne Billikens | Central League | Class B | None | 1908 | 1910 | Returned to Central League play |
| Fort Wayne Brakies | Central League | Class B | None | 1911 | 1911 | Continued Central League play with new nicknams |
| Fort Wayne Railroaders | Central League | Class B | None | 1912 | 1912 | League champions |
| Fort Wayne Champs | Central League | Class B | None | 1913 | 1913 | New nickname after winning championship in 1912 |
| Fort Wayne Railroaders | Central League | Class B | None | 1914 | 1914 | Continued Central League play |
| Fort Wayne Cubs | Central League | Class B | None | 1915 | 1915 | Continued Central League play. |
| Fort Wayne Chiefs | Central League | Class B | Cleveland Indians (1932) | 1917 1928 1932 1934 |
1917 1930 1932 1934 |
League champions 1928, 1934 |
| Fort Wayne Chiefs | Illinois-Indiana-Iowa League | Class B | None | 1935 | 1935 | Replaced by Moline Plowboys in league play. |
| Fort Wayne Generals | Central League | Class A | Pittsburgh Pirates | 1948 | 1948 | Replaced by Charleston Senators in league play. |
| Fort Wayne Daisies | All-American Girls Professional Baseball League | Women's | None | 1945 | 1954 | The Daisies played for the duration of the league. |
| Fort Wayne Wizards | Midwest League | Class A | Minnesota Twins (1993-1998) San Diego Padres (1999-2008) |
1993 | 2008 | Kenosha Twins relocated to Fort Wayne |
| Fort Wayne TinCaps | Midwest League | Class A | San Diego Padres (2009-2024) | 2009 | 2024 | 2009 league champions. |