Saint Anastasia or Santa Anastasia may refer to one of several saints, including:
- Basilissa and Anastasia of Rome (fl. c. 68), martyrs
- Anastasia the Roman (fl. c. 253), martyr
- Anastasia of Sirmium from Rome (fl. c. 304), martyr who is commemorated in the Canon of the Mass
- Anastasia the Patrician from Byzantium (fl. 576), Byzantine lady-in-waiting and hermit in Egypt
- Athanasia of Aegina (also Anastasia; c. 790–860), who lived in the Byzantine Empire and advised Empress Theodora II
- Saint Anastasia of Serbia (fl. 1196), Princess consort of Serbia
- Grand Duchess Anastasia Nikolaevna of Russia, canonized by the Russian Orthodox Church in 2000
See also
- Saint Anastasia (disambiguation), for the use of the term other than for people
- Anastasia (disambiguation)
- Anastasia (name)