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List of side effects of doxepin

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The antidepressant drug doxepin has been associated with a number of different adverse effects, including the following.

The incidence of these adverse effects is not totally known as the scarcity of well-designed clinical trials involving doxepin prohibits it. Side effects that are common (based on its pharmacology or the frequency of these side effects with related agents) appear with a * superscript whereas the serious side effects are in bold. Doxepin is licensed to be used in much smaller doses (viz., 3mg and 6 mg) in some countries, the side-effects profile of which may differ from this list.

  • Nausea
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Constipation
  • Blurred vision
  • Headache
  • Urinary hesitancy
  • Agitation
  • Hypotension (low blood pressure)
  • Hypertension (high blood pressure)
  • Tachycardia (high heart rate)
  • Skin rash
  • Facial oedema
  • Photosensitisation
  • Urticaria (hives)
  • Pruritus (itching)
  • Indigestion
  • Bone fractures
  • Taste disturbances
  • Diarrhoea
  • Anorexia (weight loss)
  • Aphthous stomatitis (canker sores)
  • Gynaecomastia (swelling of the breasts in men)
  • Galactorrhoea (lactation that is unassociated with breast feeding or pregnancy)
  • Chills
  • Fatigue
  • Weakness
  • Flushing
  • Alopecia (hair loss)
  • Eosinohpilia
  • Blood dyscrasias (abnormalities in the cellular composition of blood)
  • Increased liver function tests
  • Hyperpyrexia (high fever ≥41.5 °C or 106.7 °F)
  • Seizures
  • Confusion
  • Malaise
  • Increased appetite
  • Changes in ECG parameters (e.g. QRS & PR interval)
  • Ataxia
  • Hallucinations
  • Paraesthesias
  • Nervousness
  • Numbness
  • Tinnitus
  • Hepatitis (liver swelling)
  • Exacerbation of asthma
  • Hepatic (liver) abnormalities
  • Urinary retention
  • Extrapyramidal symptoms
  • Testicular swelling
  • Hyperglycaemia (high blood sugar)
  • Hypoglycaemia (low blood sugar)
  • Hyponatraemia (low blood sodium)
  • Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
  • Closed-angle glaucoma
  • Alzheimer's disease or dementia*

References

  1. "Sinepin Capsules 25mg - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Marlborough Pharmaceuticals Ltd. 22 September 2011. Retrieved 3 December 2013.
  2. "Deptran Doxepin (as hydrochloride)" (PDF). TGA eBusiness Services. Alphapharm Pty Ltd. 6 May 2013. Retrieved 3 December 2013.
  3. "Silenor (doxepin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 3 December 2013.
  4. Gray, Shelly L.; Anderson, Melissa L. (January 26, 2015). "Cumulative Use of Strong Anticholinergics and Incident Dementia: A Prospective Cohort Study". JAMA Intern. Med. 175 (3): 401–7. doi:10.1001/jamainternmed.2014.7663. PMC 4358759. PMID 25621434. Retrieved January 27, 2015.
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