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This is a list of the Los Premios MTV Latinoamérica winners and nominees for Best Artist — Central.
| Year | Winner | Other nominees |
|---|---|---|
| 2002 | Líbido | |
| 2003 | Líbido | |
| 2004 | TK | |
| 2005 | Shakira | |
| 2006 | Juanes | |
| 2007 | Kudai | |
| 2008 | Juanes | |
| 2009 | Don Tetto |