Luis Blanco may refer to:
- Luis Blanco Lugo (1921–1973), Puerto Rican judge
- Luis Manuel Blanco (born 1953), Argentine football manager of Mons Calpe and former forward
- Luis Blanco (footballer, born 1978), Spanish football manager of Espanyol and former forward
- Luis Blanco (footballer, born 1990), Andorran football midfielder for Santa Coloma
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