Luis Ruiz may refer to:
- Luis Ruiz Tagle (1898–?), Chilean sports shooter
- Luis Ruiz Suárez (1913–2011), Spanish missionary
- Luis Ruiz (footballer, born 1987), Colombian footballer
- Luis Ruiz (footballer, born 1992), Spanish footballer
- Luis Ruiz (footballer, born 1997), Venezuelan footballer
- Luis Ruiz (Oz), a character on the TV series Oz
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