Luther Johnson may refer to:
- Luther Alexander Johnson (1875–1965), American politician
- Luther Johnson (racing driver) (1903–1978), American racecar driver
- Luther Johnson (Guitar Junior) (1939–2022), American Chicago blues singer and guitarist
- Luther "Georgia Boy" Johnson (1934–1976), American Chicago blues guitarist and singer
- Luther "Houserocker" Johnson (1939–2019), American electric blues singer, guitarist, and songwriter
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