M&B may refer to:
- May & Baker, a British chemical company
- The drug Sulfapyridine, manufactured by May & Baker
- Mills & Boon, the romance imprint of British publisher Harlequin UK Ltd.
- Meridian and Bigbee Railroad, a U.S. railroad
- Mount & Blade, a computer game
- Mitchells & Butlers, a British pub chain company
- Mitchells & Butlers Brewery
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