Misplaced Pages

M62812

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Chemical compound Pharmaceutical compound
M62812
Identifiers
IUPAC name
  • 6-(2-aminophenoxy)-1,2-benzothiazol-3-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H11N3OS
Molar mass257.31 g·mol
3D model (JSmol)
SMILES
  • C1=CC=C(C(=C1)N)OC2=CC3=C(C=C2)C(=NS3)N
InChI
  • InChI=1S/C13H11N3OS/c14-10-3-1-2-4-11(10)17-8-5-6-9-12(7-8)18-16-13(9)15/h1-7H,14H2,(H2,15,16)
  • Key:HQCTTYOADNAJJR-UHFFFAOYSA-N

M62812 is a drug which acts as a potent and selective antagonist of toll-like receptor 4 (TLR4). In animal studies it blocks TLR4-mediated cytokine release and has antiinflammatory effects, showing efficacy in animal models of arthritis and septic shock.

See also

References

  1. Nakamura M, Shimizu Y, Sato Y, Miyazaki Y, Satoh T, Mizuno M, et al. (August 2007). "Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice". European Journal of Pharmacology. 569 (3): 237–43. doi:10.1016/j.ejphar.2007.05.013. PMID 17588563.
  2. Park H, Hong J, Yin Y, Joo Y, Kim Y, Shin J, et al. (October 2020). "TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model". Scientific Reports. 10 (1): 17451. Bibcode:2020NatSR..1017451P. doi:10.1038/s41598-020-74544-5. PMC 7567100. PMID 33060735.


Stub icon

This pharmacology-related article is a stub. You can help Misplaced Pages by expanding it.

Categories: