Misplaced Pages

MAP4K1

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.

Protein-coding gene in the species Homo sapiens
MAP4K1
Identifiers
AliasesMAP4K1, HPK1, mitogen-activated protein kinase kinase kinase kinase 1
External IDsOMIM: 601983; MGI: 1346882; HomoloGene: 5199; GeneCards: MAP4K1; OMA:MAP4K1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)
Chromosome 19 (human)Genomic location for MAP4K1Genomic location for MAP4K1
Band19q13.2Start38,587,641 bp
End38,618,882 bp
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)
Chromosome 7 (mouse)Genomic location for MAP4K1Genomic location for MAP4K1
Band7|7 B1Start28,681,475 bp
End28,702,704 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • lymph node

  • spleen

  • appendix

  • bone marrow cells

  • blood

  • monocyte

  • tonsil

  • testicle

  • sural nerve
Top expressed in
  • mesenteric lymph nodes

  • spleen

  • thymus

  • spermatid

  • blood

  • ankle joint

  • morula

  • granulocyte

  • embryo

  • embryo
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11184

26411

Ensembl

ENSG00000282928
ENSG00000104814

ENSMUSG00000037337

UniProt

Q92918

P70218

RefSeq (mRNA)

NM_001042600
NM_007181

NM_008279
NM_001355054

RefSeq (protein)

NP_001036065
NP_009112

NP_032305
NP_001341983

Location (UCSC)Chr 19: 38.59 – 38.62 MbChr 7: 28.68 – 28.7 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene. It is also known as HPK1 (Hematopoietic Progenitor Kinase 1). The protein has been shown to play a role in JNK activation.

Interactions

MAP4K1 has been shown to interact with:

References

  1. ^ ENSG00000104814 GRCh38: Ensembl release 89: ENSG00000282928, ENSG00000104814Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000037337Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH (Dec 1996). "Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade". Genes Dev. 10 (18): 2251–64. doi:10.1101/gad.10.18.2251. PMID 8824585.
  6. Chuang HC, Wang X, Tan TH (2016). MAP4K Family Kinases in Immunity and Inflammation. Advances in Immunology. Vol. 129. pp. 277–314. doi:10.1016/bs.ai.2015.09.006. ISBN 9780128047996. PMID 26791862. {{cite book}}: |journal= ignored (help)
  7. Tsuji S, Okamoto M, Yamada K, Okamoto N, Goitsuka R, Arnold R, Kiefer F, Kitamura D (Aug 2001). "B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1". J. Exp. Med. 194 (4): 529–39. doi:10.1084/jem.194.4.529. PMC 2193495. PMID 11514608.
  8. ^ Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM (Oct 1998). "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". Oncogene. 17 (15): 1893–901. doi:10.1038/sj.onc.1202108. PMID 9788432. S2CID 19885101.
  9. ^ Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, Tan TH (Feb 1999). "Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase". Mol. Cell. Biol. 19 (2): 1359–68. doi:10.1128/MCB.19.2.1359. PMC 116064. PMID 9891069.
  10. ^ Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Hu MC, Wange RL, Tan TH (Jun 2001). "Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling". J. Biol. Chem. 276 (22): 18908–14. doi:10.1074/jbc.M101485200. PMID 11279207.
  11. Ensenat D, Yao Z, Wang XS, Kori R, Zhou G, Lee SC, Tan TH (Nov 1999). "A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1". J. Biol. Chem. 274 (48): 33945–50. doi:10.1074/jbc.274.48.33945. PMID 10567356.
  12. Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan TH, Liu M (Mar 2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene. 20 (14): 1703–14. doi:10.1038/sj.onc.1204224. PMID 11313918. S2CID 25646725.
  13. ^ Anafi M, Kiefer F, Gish GD, Mbamalu G, Iscove NN, Pawson T (Oct 1997). "SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1". J. Biol. Chem. 272 (44): 27804–11. doi:10.1074/jbc.272.44.27804. PMID 9346925.


Stub icon

This article on a gene on human chromosome 19 is a stub. You can help Misplaced Pages by expanding it.

Categories: